Mathias V. Schmidt

Mathias V. Schmidt

@mathiasvschmidt.bsky.social

Unraveling the molecular basis of stress resilience | Group leader at MPI of Psychiatry | Secretary General Elect of FENS | Editor-in-Chief Neurobiology of Stress

1.7K followers446 following70 posts

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Mathias V. Schmidt
@mathiasvschmidt.bsky.social

New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...

nature.comFKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature CommunicationsEarly life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...
Mathias V. Schmidt
@mathiasvschmidt.bsky.social

𝘚𝘦𝘢𝘮𝘭𝘦𝘴𝘴 𝘐𝘯𝘵𝘦𝘨𝘳𝘢𝘵𝘪𝘰𝘯: Works directly with all top-down recorded tests like OpenField, EPM, Fear Conditioning, Social Interaction, etc. 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘥 𝘚𝘱𝘢𝘵𝘪𝘢𝘭 𝘔𝘦𝘵𝘳𝘪𝘤𝘴: Automatically detect experimental arenas, define custom Regions of Interest (ROIs), and run complex downstream spatial-behavioral analyses.

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

𝘍𝘭𝘦𝘹𝘪𝘣𝘭𝘦 𝘌𝘯𝘷𝘪𝘳𝘰𝘯𝘮𝘦𝘯𝘵𝘴: Run it locally or straight out of the cloud using Google Colab. 🎥 Get Started in Minutes We have put together a comprehensive, step-by-step video guide that walks you through the entire installation, virtual environment setup, and running your first tutorial project:

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

𝐃𝐞𝐞𝐩𝐎𝐅 bridges this gap. Our open-source Python package offers an end-to-end pipeline for high-throughput, high-resolution deep phenotyping—fully accessible to the wider scientific community without requiring programming expertise.

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

🔍 What can you do with DeepOF? 𝘚𝘶𝘱𝘦𝘳𝘷𝘪𝘴𝘦𝘥 & 𝘜𝘯𝘴𝘶𝘱𝘦𝘳𝘷𝘪𝘴𝘦𝘥 𝘈𝘯𝘢𝘭𝘺𝘴𝘪𝘴: Detect pre-programmed behaviors (using built-in classifiers) or train machine learning models to discover entirely new, unbiased, unsupervised behavioral states.

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

What is 𝐃𝐞𝐞𝐩𝐎𝐅? Understanding animal behavior in high resolution is one of the greatest challenges in modern neuroscience. While deep learning tools have revolutionized pose estimation, translating the data into meaningful behavioral insights requires specialized setups and computational skills.

Mathias V. Schmidt reposted

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

Stress and resilience researchers - check out this fantastic satellite event just before the start of the European College of Neuropsychopharmacology (ECNP) Meeting in Munich. We have a fantastic lineup of speakers. Registration (free) is now open: lnkd.in/gMsV4Ygc

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬 I am thrilled to announce an editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. With @bartolomuccilab.bsky.social, I am co-editing a virtual special issue focused on: 𝘚𝘵𝘳𝘦𝘴𝘴-𝘪𝘯𝘥𝘶𝘤𝘦𝘥 𝘪𝘮𝘱𝘢𝘪𝘳𝘦𝘥 𝘩𝘦𝘢𝘭𝘵𝘩 𝘢𝘯𝘥 𝘢𝘤𝘤𝘦𝘭𝘦𝘳𝘢𝘵𝘦𝘥 𝘢𝘨𝘪𝘯𝘨

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Mathias V. Schmidt
@mathiasvschmidt.bsky.social

𝐏𝐫𝐢𝐦𝐚𝐫𝐲 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡: Submit to Neurobiology of Stress (Select: “VSI: Stress and aging (YNSTR)”) 𝐑𝐞𝐯𝐢𝐞𝐰𝐬 & 𝐏𝐞𝐫𝐬𝐩𝐞𝐜𝐭𝐢𝐯𝐞𝐬: Submit to Neuroscience & Biobehavioral Reviews (Select: “VSI: Stress and aging (NBR)”)

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬 I am thrilled to announce an editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. With @bartolomuccilab.bsky.social, I am co-editing a virtual special issue focused on: 𝘚𝘵𝘳𝘦𝘴𝘴-𝘪𝘯𝘥𝘶𝘤𝘦𝘥 𝘪𝘮𝘱𝘢𝘪𝘳𝘦𝘥 𝘩𝘦𝘢𝘭𝘵𝘩 𝘢𝘯𝘥 𝘢𝘤𝘤𝘦𝘭𝘦𝘳𝘢𝘵𝘦𝘥 𝘢𝘨𝘪𝘯𝘨

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

Looking back at the past year, the field of stress neurobiology has seen incredible growth. Our journal had the privilege of publishing groundbreaking work that pushes the boundaries of how we understand the bodies response to challenge and its impact to health and disease.

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

I’m thrilled to share our latest preprint from the lab, now available on BioRxiv! We investigated how early life adversity (ELA) shapes the adult brain, and the results are a stark reminder that sex isn't just a variable but leads to fundamentally different stress-induced mechanistic consequences

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.

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Mathias V. Schmidt
@mathiasvschmidt.bsky.social

We provide: - A standardized workflow for long-term home-cage monitoring in mice. - A practical guidance on experimental setups for 24-hour recordings. - A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases .. and much more!

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

Check out our new paper in Neuroscience & Biobehavioral Reviews: "𝑳𝒐𝒏𝒈-𝒕𝒆𝒓𝒎 𝒅𝒆𝒆𝒑 𝒑𝒉𝒆𝒏𝒐𝒕𝒚𝒑𝒊𝒏𝒈 𝒐𝒇 𝒃𝒆𝒉𝒂𝒗𝒊𝒐𝒓𝒂𝒍 𝒕𝒓𝒂𝒊𝒕𝒔 𝒊𝒏 𝒎𝒊𝒄𝒆 𝒖𝒔𝒊𝒏𝒈 𝒉𝒐𝒎𝒆𝒄𝒂𝒈𝒆 𝒎𝒐𝒏𝒊𝒕𝒐𝒓𝒊𝒏𝒈" This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...

sciencedirect.comLong-term deep phenotyping of behavioral traits in mice using homecage monitoringNeuropsychiatric disorders represent a significant global health challenge, and a deeper understanding of their underlying neurobiology is urgently ne…

Mathias V. Schmidt reposted

Natalie Matosin
@nataliematosin.bsky.social

Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in: www.biorxiv.org/content/10.1...

biorxiv.orgAstrocytic glutamate regulation is shaped by adversity and glucocorticoid signallingAstrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...

Mathias V. Schmidt reposted

Natalie Matosin
@nataliematosin.bsky.social

🚨 NEW PAPER 🚨 Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...

sciencedirect.comExpanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptidesSteroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…

Mathias V. Schmidt reposted

EARA
@eara.eu

The Be Open about Animal Research Day is starting now! Show your support and share on #BOARD25

Mathias V. Schmidt
@mathiasvschmidt.bsky.social

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

cell.comThe evolving neurobiology of early-life stressThis review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...

Mathias V. Schmidt reposted

Jamie Hanson
@jamielarsh.bsky.social

Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...

sciencedirect.comChildhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatryAutoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…

Mathias V. Schmidt reposted

Bertoglio lab (FMC/UFSC)
@bertogliolab.bsky.social

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis www.nature.com/articles/s41...

nature.comMaternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis - Nature CommunicationsEarly life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promo...

Mathias V. Schmidt reposted

Leander
@le-and-er.bsky.social

🚨🧠 New paper alert: Stress alters neuronal balance in the developing brain 🧠🚨 Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids. @mpi-psychiatry.bsky.social @drcricru.bsky.social 🧵👇

science.orgChronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoidsChronic exposure to glucocorticoids during brain development leads to priming of the inhibitory neuron lineages in organoids.