Life Science Alliance

MT networks position cellularization furrows to accurately partition multinucleate S. arctica. U-ExM, perturbations, and live imaging suggest shared patterns of cytoskeletal remodelling in eukaryotes. @reviewcommons.org www.life-science-alliance.org/content/10/1...

This Commentary traces how failures along the data-information-knowledge-wisdom hierarchy mislead biomedical research and argues that rigor and falsification must govern human and machine judgment. #DIKW #AI @dokhlab @MedicineUVA www.life-science-alliance.org/content/10/1...

🧬 How is chromatin information translated into developmental decisions? Interpretation of H3K4me3 is essential for establishing embryonic patterning in Arabidopsis, linking chromatin state to key developmental decisions. New research in @LSAjournal www.life-science-alliance.org/content/10/1...

SARS-CoV-2 Nucleocapsid promotes recruitment of IRF & AP-1 transcription factors 🧬, RNA polymerase II, and eEF1A1 to pro-inflammatory gene promoters, revealing a previously unrecognized nuclear role for eEF1A1 👇 www.life-science-alliance.org/content/9/12...

Take a look at this recently published paper in LSA: Esc2 and Rad57 contribute to RNA polymerase II distribution at highly transcribed genes👇 www.life-science-alliance.org/content/10/1...

Gut microbiota and their metabolites shape MASLD progression by modulating intestinal barrier integrity, inflammation, metabolism, and liver signaling. @iimcb.bsky.social www.life-science-alliance.org/content/10/1...

More data ≠ more understanding. Commentary in LSA maps where biomedical research breaks down along the data-information-knowledge-wisdom hierarchy and why scientists and AI alike must stay open to being wrong. #DIKW #AI @dokhlab @MedicineUVA www.life-science-alliance.org/content/10/1...

PK2 is essential for *Plasmodium berghei* transmission. Its depletion impairs ookinete motility, disrupts microneme organisation, blocks oocyst and sporozoite development, and alters invasion-related phosphorylation. @reviewcommons.org www.life-science-alliance.org/content/9/12...

Gierse et al. show that ROCK1's PHC1 domain is recruited to elevated cortical Rho activity, that it cooperates with the Rho-binding domain (RBD), and that it participates in cell contraction signaling. @tu-dortmund.de www.life-science-alliance.org/content/9/12...

📢 Autolysosomal enhancer GHF201 attenuates pathophysiology in a mucopolysaccharidosis-I mouse model 👇 www.life-science-alliance.org/content/9/12...

This study links macrophage dysferlin to Ca²⁺-dependent STAT1-associated inflammatory responses and impaired myogenic differentiation in cellular models. www.life-science-alliance.org/content/9/12...

Allele-specific profiling of ribosome-associated mRNAs reveals widespread cis-regulatory effects on translation and shows that 80S monosome analysis improves detection sensitivity. www.life-science-alliance.org/content/9/12...

Haplotype-resolved genome of a dry-preservable cell line reveals chromosome evolution and DNA damage www.life-science-alliance.org/content/9/12...

The study shows that interpretation of H3K4me3 is essential for translating chromatin information into the developmental decisions that establish embryonic patterning in Arabidopsis. www.life-science-alliance.org/content/10/1...

SARS-CoV-2 Nucleocapsid promotes recruitment of IRF and AP-1 transcription factors, RNA polymerase II, and the elongation factor eEF1A1 to promoters of pro-inflammatory genes, revealing a previously unrecognized nuclear role for eEF1A1. www.life-science-alliance.org/content/9/12...

Recombination-related factors are linked to gene-body Pol II occupancy and transcription-associated chromatin states at highly active genes in yeast. www.life-science-alliance.org/content/10/1...

The review highlights how gut microbiota alterations and microbial metabolites drive MASLD progression, influencing metabolism, inflammation, and gut barrier integrity. @iimcb.bsky.social www.life-science-alliance.org/content/10/1...

PK2 is key to *Plasmodium berghei* transmission. Its depletion impairs ookinete motility, disrupts microneme organisation, blocks sporozoite development, and alters invasion-related phosphorylation. @reviewcommons.org www.life-science-alliance.org/content/9/12...

A new piece of the Rho-ROCK signaling puzzle. This study reveals that the C-terminal PHC1 domain of ROCK1 helps recruit the kinase to active Rho signaling zones and contributes to transmitting Rho activity into cell contraction. @tu-dortmund.de www.life-science-alliance.org/content/9/12...

This work demonstrates that the autolysosomal enhancer GHF201 attenuates pathophysiology in an MPS-I mouse model. www.life-science-alliance.org/content/9/12...

Macrophage dysferlin regulates Ca²⁺-dependent STAT1-associated inflammatory responses and influences myogenic differentiation in cellular models. www.life-science-alliance.org/content/9/12...

Using allele-resolved RNA sequencing of total, monosome-, and polysome-associated mRNAs in RPE-1 cells, this study identifies 1,247 cis-regulatory genetic variants in 1,015 genes linked to allele-specific translational regulation. www.life-science-alliance.org/content/9/12...

This study establishes a diploid genome resource for desiccation-tolerant insect cells, enabling new insights into genome organization and stress-associated DNA damage. www.life-science-alliance.org/content/9/12...

TTF2 restrains RNA Polymerase I reactivation at mitotic exit, and its loss triggers premature rRNA synthesis and nucleolar fragmentation. @raoliveira.bsky.social @reviewcommons.org www.life-science-alliance.org/content/9/12...

PZL-26 targets LONP1 with nanomolar potency and on-target cellular activity, revealing OXPHOS and mitochondrial gene expression as key survival dependencies. www.life-science-alliance.org/content/9/12...

🧠 What drives human cortical expansion? Conserved MEIS1 plays a key role, regulated by a human-specific non-coding RNA that coordinates primary cilia morphology and preserves neural progenitor proliferation. www.life-science-alliance.org/content/9/12...

Take a look at this recently published paper in LSA: The non-coding RNA GRAS1 interacts with NKAP and protects against DNA damage and cell death @ucsdchem.bsky.social 👇 www.life-science-alliance.org/content/9/12...

New function! TTF2 has a role in restricting RNA Polymerase I reactivation at mitotic exit, ensuring proper synthesis of rDNA and nucleolar organisation. @raoliveira.bsky.social @reviewcommons.org www.life-science-alliance.org/content/9/12...

New study: PZL-26 selectively inhibits mitochondrial protease LONP1, sparing the proteasome. CRISPR screening and proteomics reveal LONP1's roles in OXPHOS and mitochondrial gene expression. www.life-science-alliance.org/content/9/12...

Conserved MEIS1 drives human cortical expansion. A human-specific non-coding RNA regulates MEIS1 to coordinate primary cilia morphology, preserving neural progenitor proliferation. www.life-science-alliance.org/content/9/12...

This study uses a combination of molecular biochemistry and cell biology approaches to identify a novel function for a non-coding RNA and protein interaction in promoting human cell survival. @ucsdchem.bsky.social www.life-science-alliance.org/content/9/12...

Check out this recently published paper in LSA: Murine IL-2 outperforms human IL-2 in supporting the survival of naïve mouse CD8 T cells in vitro ➡️ www.life-science-alliance.org/content/9/12... @bsheridanlab.bsky.social @stonybrookmedicine.bsky.social

In our October issue: Combining two spatial transcriptomics probe sets on the same sample, how epithelial cells remember prior physical constraints, and a novel single-cell translation profiling technique! www.life-science-alliance.org/content/9/10

Check out this recently published paper in LSA: Proteomics of heterogeneous megakaryocytes identifies JI051 as an enhancer of platelet biogenesis ➡️ www.life-science-alliance.org/content/9/12...

New Research paper in LSA: Fetal growth restriction leads to prolonged nephrogenesis and gene dysregulation in the adult kidney👇 www.life-science-alliance.org/content/9/11...

This study shows that an N-terminal degradation tag can alter RAF1 function before protein removal, highlighting the need to validate tagged proteins in disease models. www.life-science-alliance.org/content/9/12...

Murine IL-2 promotes the survival of naïve mouse CD8 T cells in vitro compared to human IL-2 and induces a distinct expression pattern of IL-2 receptors in activated CD8 T cells. @bsheridanlab.bsky.social @stonybrookmedicine.bsky.social www.life-science-alliance.org/content/9/12...

Drug-induced metabolic remodeling promotes antimicrobial activity in macrophages and extends longevity in vivo @rutgersuniversity.bsky.social @rutgersresearch.bsky.social www.life-science-alliance.org/content/9/12...

This study establishes a proteomics platform to elucidate megakaryocyte heterogeneity and identifies JI051 as a compound that enhances platelet-like particle generation with bioproduction potential. www.life-science-alliance.org/content/9/12...

A mouse model of fetal growth restriction reveals prolonged kidney development and gene dysregulation in adulthood, suggesting that late gestational and early postnatal periods are crucial for preventing chronic kidney disease (CKD). www.life-science-alliance.org/content/9/11...

New research shows that an N-terminal dTAG cassette alters RAF1 scaffold function in KRAS-driven lung cancer models before degradation, underscoring the importance of validating tagged proteins. #CancerResearch #TPD www.life-science-alliance.org/content/9/12...

A potent antimicrobial promotes mitochondrial fission & mitophagy, boosting the effectiveness of macrophages to defend against bacterial infection & promoting lifespan extension in C. elegans. @rutgersuniversity.bsky.social @rutgersresearch.bsky.social www.life-science-alliance.org/content/9/12...