LPJ Lab - Neuroimmunometabolism

LPJ Lab - Neuroimmunometabolism

@lpjlab.org

Welcome to Luca Peruzzotti-Jametti's lab @University of Cambridge! We're dedicated to investigating how cell #metabolism shapes #brain - #immune interactions to pioneer new therapies for #MultipleSclerosis and other CNS disorders. https://www.LPJLab.org

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LPJ Lab - Neuroimmunometabolism
@lpjlab.org

What an incredible few days at #ICBEM2026 in Barcelona! 🇪🇸 I had amazing fun co-chairing the session on #microglia and #metabolism, as well as sharing our work on how to stop chronic #brain inflammation 🚫🔥🧠 So inspired by this community! ✨🚀

LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Honoured to be shortlisted for the Neurology INNLIFES award! As the winner is decided by public vote, I would truly appreciate yours. Please vote for Peruzzotti-Jametti under "Protagonisti dell’innovazione Neurologia". Shares are also a huge help! Thanks! www.indicon-innovation.tech/premio-i-pro...

indicon-innovation.techPremio I Protagonisti dell’innovazione 2026Come funziona il Premio Il Premio “I Protagonisti dell’Innovazione 2026” nasce con l’obiettivo di valorizzare professionisti, organizzazioni e startup che, nel corso del 2025, si sono distinti per la ...

LPJ Lab - Neuroimmunometabolism reposted

Joe Sabatino
@jsabatino37.bsky.social

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset onlinelibrary.wiley.com/doi/full/10....

onlinelibrary.wiley.comEpstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset[Color figure can be viewed at www.annalsofneurology.org]
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

⚠️ We are hiring a Postdoctoral Research Associate ⚠️ 🚨 Deadline 9th February 2026 🚨 👍 Please like and share with your network! 👍 #CambridgeUniversity #PostdoctoralResearch #JobOpportunity For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...

cam.ac.ukPostdoctoral Research Associate (Fixed Term)Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced

LPJ Lab - Neuroimmunometabolism reposted

Science X / Phys.org
@sciencex.bsky.social

A new CRISPR-based approach has identified key immune signals that regulate macrophage behavior in multiple sclerosis, offering deeper insight into the mechanisms driving neuroinflammation. doi.org/hbjfrf

medicalxpress.comNew insight into the immune signals driving inflammation in multiple sclerosisMultiple sclerosis (MS) is a chronic neurological disease characterized by nerve damage and consequent impairments in vision, movement, balance and mental function.

LPJ Lab - Neuroimmunometabolism reposted

Nature Metabolism
@natmetabolism.nature.com

REVIEW | E Asimakidou, @lpjlab.org et al. (U Cambridge) How metabolic interactions between microglia and neurons shape brain health 🧪

dlvr.itThe metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature MetabolismThis Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

New research in Nature Metabolism reveals that neuronal fatty acid oxidation is crucial for fueling memory formation after intensive learning. This metabolic shift supports the high energy demands in fruit flies. 🧠🪰 #Neuroscience #Metabolism #Memory www.nature.com/articles/s42...

nature.comNeuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature MetabolismNeurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy…
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

⚠️ Just out in @natmetabolism.nature.com ⚠️ Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠 Our Evridiki Asimakidou did a wonderful job leading this! 👏 www.nature.com/articles/s42...

nature.comThe metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature MetabolismThis Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

LPJ Lab - Neuroimmunometabolism reposted

Michael Platten, MD
@michael-platten.bsky.social

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/... Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

science.orgThe immunology of brain tumorsThe cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

New preprint: #Microglia don't just clear debris - they undergo a massive metabolic overhaul after phagocytosis, including adaptive mitochondrial changes, which may make them pro-regenerative! 🥳🧠💪 #Neuroscience #Mitochondria #Metabolism #BioRxiv www.biorxiv.org/content/10.1...

biorxiv.orgMetabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative propertiesPhagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

#PhD position available! Our collaborator Roberta Magliozzi is looking for a motivated student to map the meningeal immune landscape in #MultipleSclerosis. This is a great opportunity for anyone interested in neuroimmunology! 🧠 Please SHARE and APPLY here: www.imperial.ac.uk/brain-scienc...

imperial.ac.ukFundingFunding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...

LPJ Lab - Neuroimmunometabolism reposted

Cambridge Neuroscience
@camneuro.bsky.social

Session Six featured fantastic talks by Prof. Vendeuscolo from the Dept. of Chemistry @cam.ac.uk, Prof. Peruzzotti-Jametti from the Dept. of Clinical Neurosciences @cam.ac.uk, and the Andrew Huxley Plenary Lecture by our special guest Prof. Studer from the Sloan Kettering Cancer Center, NY #CNS2025

LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Human myelinated brain organoids with integrated #microglia as a model for #myelin repair and remyelinating therapies | Science Translational Medicine www.science.org/doi/10.1126/...

science.orgHuman myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapiesHuman myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

LPJ Lab - Neuroimmunometabolism reposted

GregoryAi
@gregoryai.bsky.social

An interview with Dr. Luca Peruzzotti Jametti on the topic of #Myelin repair. ms-perspektive.de/en/129-luca-... #MSchat #MultipleSclerosis #Neurology #StemCells @pluchinolab.bsky.social @restorems.bsky.social @lpjlab.org

ms-perspektive.deHope for Myelin Repair: Stem Cells & Progressive MSCan neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience! www.cell.com/cell/fulltex...

cell.comSingle-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilienceA single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧 We had a great chat about the latest research in MS and how we're working to find new treatments. 💪 Listen to the full episode here 👇 ms-perspektive.com/129-luca-per...

ms-perspektive.comHope for Myelin Repair: Stem Cells & Progressive MSCan neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

LPJ Lab - Neuroimmunometabolism reposted

Cytosurge AG
@cytosurge.bsky.social

Replying to @lpjlab.org

www.nature.com/articles/s43... reproduced in vitro thanks to #FluidFM

nature.comMIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation - Nature CancerCangkrama et al. show that tumor cells from various cancer types use the mitochondrial trafficking protein MIRO2 and nanotubes to transfer mitochondria into surrounding fibroblasts, thereby inducing c...

LPJ Lab - Neuroimmunometabolism reposted

Nature Metabolism
@natmetabolism.nature.com

PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis) An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab

bit.lySynthetic torpor: advancing metabolic regulation for medical innovations - Nature MetabolismChen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

The debate on intercellular mitochondrial transfer is heating up! In this new Viewpoint, eminent scientists in the field of mitochondrial biology, including our friend @rubenqc-lab.bsky.social, share their views on the topic. Dive in and let us know what you think! www.nature.com/articles/s42...

nature.comMitochondrial transfer - Nature MetabolismIntercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticis...

LPJ Lab - Neuroimmunometabolism reposted

RyanLab_TCD
@ryanlab.bsky.social

The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism Great work from @lydialynch.bsky.social lab and colleagues www.nature.com/articles/s42...

nature.comThe source of dietary fat influences anti-tumour immunity in obese mice - Nature MetabolismThis study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

What a night! Our lab traded pipettes for axes, and let's just say we honed our missing skills with expert precision! 😉 It was an absolute blast seeing everyone de-stress and have a laugh, no matter where the axes landed 🪓🎯 Huge thanks to everyone! 👏 #Neuroscience #AxeThrowing #TeamBuilding

LPJ Lab - Neuroimmunometabolism
@lpjlab.org

A super cool #single-cell spatial transcriptomic mouse #brain atlas is out! 🐭🧠🔬 Unveiling cell types, #gene expression, & TF dynamics across the whole brain! Awesome! ✨ #neuroskyence #neuroscience #compneurosky www.cell.com/neuron/fullt...

cell.comSingle-cell spatial transcriptomic atlas of the whole mouse brainHan et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters a...
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Thrilled to share our latest paper showing that the transplantation of directly induced neural #StemCells enhances #remyelination of chronic demyelinating lesions! 💉🧠=💪 A great team effort with @pluchinolab.bsky.social and all our collaborators! #MultipleSclerosis academic.oup.com/brain/advanc...

academic.oup.comRemyelination of chronic demyelinated lesions with directly induced neural stem cellsPeruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts. They show that i
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Biotechnological approaches and therapeutic potential of #mitochondria transfer and transplantation 💉 www.nature.com/articles/s41...

nature.comBiotechnological approaches and therapeutic potential of mitochondria transfer and transplantation - Nature CommunicationsMitochondrial dysfunction is involved in several disease states, mitochondria transfer and transplantation have the potential to address this. Here, the authors review recent advancements and cha...
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Get ready for a scientific breakthrough! 🧑‍🔬 #DeepMind AlphaGenome is here: cutting-edge #AI to decode the mysteries of the human #genome! This isn't just about data; it's about unlocking entirely new ways to understand health & disease #Genomics #FutureOfMedicine deepmind.google/discover/blo...

deepmind.googleAlphaGenome: AI for better understanding the genomeIntroducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

📢 Exciting Welcome to Sinéad and Ishan! 📢 We're thrilled to welcome both to the LPJ Lab for their #SummerInternship! Under Evridiki's guidance, they'll contribute to the understanding of #Microglia in #MultipleSclerosis. Here's to a #summer of groundbreaking neurobiology and exciting insights!

LPJ Lab - Neuroimmunometabolism
@lpjlab.org

The immunoproteasome modulates cell metabolism and actively drives neurodegeneration in #MultipleSclerosis. This really underscores the complex interplay between #immunity, #metabolism, and #brain health! 🧠 #Neuroscience #Neuroskyence www.cell.com/cell/fulltex...

cell.comThe immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosisNeuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Ferroptosis contributes to #MultipleSclerosis and its pharmacological targeting suppresses experimental disease progression www.nature.com/articles/s41...

nature.comFerroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression - Cell Death & DifferentiationCell Death & Differentiation - Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Diving deep into neuroinflammation's impact on neurological disorders! This latest review masterfully synthesizes findings across #MS, stroke, #Alzheimer's, and #Parkinson's, offering crucial insights for the field. #neurology #neuroscience #neuroskyence www.science.org/doi/10.1126/...

science.orgNeuroinflammation across neurological diseasesThe brain’s response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the “flame” of the brain. Although details diff...
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in #multiplesclerosis www.nature.com/articles/s41...

nature.comBroad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis - Nature MedicineThis study identifies a unique multiple sclerosis lesion, the broad rim lesion, which is associated with rapid disease progression and marked by a distinct inflammatory profile involving innate inflam...

LPJ Lab - Neuroimmunometabolism reposted

Cell Press
@cellpress.bsky.social

Replying to @cellpress.bsky.social

"An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons" www.cell.com/cell-reports... Xiangmin Xu & colleagues @cp-cellrepmethods.bsky.social

cell.comAn AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neuronsCao et al. demonstrate excitatory neuronal tropism of the AAV capsid AAV-MG1.2 that was initially proposed for targeting microglia in the mouse brain. AAV-MG1.2 shows great promise for expanding our g...
LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Mitochondrial #DNA signals driving #immune responses: Why, How, Where? #Mitochondria biosignaling.biomedcentral.com/articles/10....

biosignaling.biomedcentral.comMitochondrial DNA signals driving immune responses: Why, How, Where? - Cell Communication and SignalingThere has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and proteostatic stresses, instability and impaired disposal of nucleoids cause t...

LPJ Lab - Neuroimmunometabolism reposted

GLIA-Leadership
@glia-leadership.bsky.social

🧠 Always solving problems but not moving forward? You might be the decision bottleneck. 📦 Try asking: “What would you do if I weren’t here?” 🌟 What’s one decision you could delegate today? #LeadershipGrowth #EmpowerYourTeam #LabLeadership #ResearchCulture

LPJ Lab - Neuroimmunometabolism
@lpjlab.org

Just presented our findings on the use of nanoparticles & extracellular vesicles 🧪 #EVs to modulate 🧠 #brain #metabolism at the Blankenese Conference in #Hamburg! A lot of inspiring science all around! blankenese-conferences.eu www.lpjlab.org/news-1/p3dufajt9awazywmaxoyoe3m0vis0v

blankenese-conferences.euBlankenese Conferences | since 1979Die Jung-Stiftung für Wissenschaft und Forschung fördert humanmedizinische Spitzenforschung durch Preise in einem Gesamtvolumen von derzeitig 540.000 Euro pro Jahr. Damit gehören die Preise zu den Höc...