John Steele reposted
Opportunity in structural biology at Concept Life Sciences (Edinburgh UK) closing: 30-Sep-2026 #StructBiol #chemsky 🧪 conceptlifesciences.peoplehr.net/Pages/JobBoa...
John Steele
@jfcsteele.bsky.social
Structural biologist and biochemist with an interest in synthetic biology for green chemistry. Unapologetic geek passionate about science and biotechnology. Postdoc at Edinburgh University- all views are my own. He/Him.
294 followers518 following47 posts
John Steele reposted
Opportunity in structural biology at Concept Life Sciences (Edinburgh UK) closing: 30-Sep-2026 #StructBiol #chemsky 🧪 conceptlifesciences.peoplehr.net/Pages/JobBoa...
John Steele reposted
New paper from our lab, led by @jfcsteele.bsky.social and @biowacko.bsky.social! Here we screen natural enzyme variants with genetic and process optimizations to produce an efficient system to convert lignin-derived waste (guaiacol) into nylon precursor, adipic acid. pubs.acs.org/doi/full/10....
It's hard to describe how valuable CASP is to the structural biology & structure prediction field. The ever increasing number of prediction algorithms means independent assessment of their accuracy is vital. Please contribute interesting/tricky structural data if you can!
Is #AI hitting a plateau in structure prediction? Help us find out at CASP17! 🧪🧬 Calling for Targets: Immune Complexes, protein - ligand complexes, RNA/DNA, conformational ensembles, membrane proteins, viral origins, and large complexes. The Rule of Thumb: If AF3 can’t model it, we want it.
It feels cheesy when people say this but it really was a privilege to be part of this work. Our recent paper (led by the fantastic Ben Royer @swallacelab.bsky.social) shows how engineered Ecoli can turn the main product of PET plastic breakdown it into an anti-Parkinsons drug (L-DOPA) rdcu.be/e84ZO
John Steele reposted
Great news that @ukri.org is substantially supporting @daphnejacksontr.bsky.social - an impactful scheme to re-start careers and access the skills of those who have taken career breaks.
The Government will more than double support for the Daphne Jackson Trust from £1.7m to £4m per year, which will help to unlock the talent of many more researchers whose careers have been paused. Find out more in our joint-statement with @ukri.org daphnejackson.org/2026/03/ukri... #ResearchReturners
John Steele reposted
Why were people obsessed with Nikola Tesla’s (lack of) sex life? What happened when work took me to a country where being gay can mean life imprisonment? Why did a queer astronaut take that secret to her grave? Some of the many Qs I covered in my #LGBTHistoryMonth talk to @aktcharity.bsky.social
John Steele reposted
Synthetically-primed evolution enables emergence of Pseudomonas putida strains able to grow on explosive residue 2,4 DNT as sole C/N source. A case of *molecular negotiation* between the implanted pathway & the host’s regulatory & physiological network 🤔 www.sciencedirect.com/science/arti...
John Steele reposted
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...
There's a lot of discussion whether economic growth & carbon emissions can be decoupled. Some critics say countries (e.g UK) reduce emissions while growing by offshoring pollution (i.e. to China). This is a fantastic rebuttal- China continues to grow economically with reduced CO2 emissions.
NEW ANALYSIS: China's CO2 has now been 'flat or falling' for 21 months * Down in 2025 * Still below Mar 2024 * Clean energy wave a key factor If this is China's peak (TBC) it's the climate story of the century so far… www.carbonbrief.org/...
John Steele reposted
Big career update: I’m honored and humbled to serve as Chair of the Department of Molecular Microbiology & Immunology at Oregon Health & Science University (OHSU). Looking forward to what we’ll build together! @ohsummi.bsky.social @ohsunews.bsky.social
John Steele reposted
No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...
John Steele reposted
John Steele reposted
Applications now open for Summer Studentships 2026! Successful applicants will be: 🌿In receipt of £504.38 per week for a studentship period of up to 6 weeks 🌿Invited to write a blog for the BiPS website 🌿Invited to attend and present at the next BiPS Conference Apply here: bit.ly/4qf2ZDG
You can't think about a sustainable chemical industry without considering our most abundant energy source: sunlight. So how can we engineer microbes to harness this energy for our benefit? rdcu.be/e1VfW
with @kittyclouston.bsky.social, Connor Trotter, @louismarlow.bsky.social & @swallacelab.bsky.social we look at re-purposing photosynthetic bacteria for chemical production, how non-evolutionary microbe-solar interfaces can be engineered, and what this means for the future of sustainable chemistry.
John Steele reposted
The very first Dr from the group! Congratulations Laura @transitionalform.bsky.social @instmolplantsci.bsky.social for passing your viva yesterday!! 🎉🎉 Thanks so much @seanhmcmahon.bsky.social and Paul Kenrick for acting as examiners
@kurzgesagt.org have some fantastic videos. This could be a great opportunity and comes at a time when having accurate and trustworthy information is more vital than ever!
JOB ALERT! 📢 For the scientists who love science communication: we’re hiring at @kurzgesagt.org !🌍 Come join our team, the vibes are impeccable. ✍️ Scriptwriter (Remote) kurzgesagt.org/careers/scri... 🔍 Fact-Checker & Researcher (Munich/Berlin/Remote) kurzgesagt.org/careers/seni...
John Steele reposted
JOB ALERT! 📢 For the scientists who love science communication: we’re hiring at @kurzgesagt.org !🌍 Come join our team, the vibes are impeccable. ✍️ Scriptwriter (Remote) kurzgesagt.org/careers/scri... 🔍 Fact-Checker & Researcher (Munich/Berlin/Remote) kurzgesagt.org/careers/seni...
John Steele reposted
Interested in parasitology? Looking to do a PhD? Cone join me and @geordieparasit.bsky.social in Edinburgh as we try and work out how human parasites get their vitamins.
🎓 Funded #PhD studentships in pathogen biology and parasitology *Cell and Molecular Biology*; *Host-pathogen interactions* Part of the EastBio Doctoral Landscape Award Based in the Edinburgh area of Scotland PhD 1: bit.ly/Host-pathoge... PhD 2: bit.ly/Parasite-sca... @uoe-eid.bsky.social
John Steele reposted
🪧 Upcoming Opportunities! We recently updated our website with some exciting opportunities. From scholarships specifically for Black students to PhD programmes across the country there are an incredible number of options. Head to our website for more details: buff.ly/uVvFtBk
John Steele reposted
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
John Steele reposted
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
John Steele reposted
Are you looking for a PhD in Plant Science? Check our our project on barley canopy architecture. Combine genetics and physics to understand how awns influence barley grain development. Find out more here: lnkd.in/eWhWammJ Apply by 14th December. #PhDPosition #PlantSci @instmolplantsci.bsky.social
John Steele reposted
John Steele reposted
Very excited to announce that our collaborative manifesto for 🌱 #PlantScience #Education has now been published! Educators from >10 countries and 30 institutions have contributed to it and we are incredibly proud of the final output. Here is a short thread 🧵1/4 doi.org/10.1002/ppp3...
John Steele reposted
Do you enjoy teaching biochemistry? The University of Virginia Department of Chemistry is hiring a teaching-track assistant professor to teach lecture and/or laboratory biochemistry courses. #chemjobs #facultychemjobs More details in the link below: apply.interfolio.com/175929
John Steele reposted
Replying to @johninnescentre.bsky.social
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...
John Steele reposted
Fully-funded #PhDposition in my lab @uniofeastanglia.bsky.social Apply before 🗓️ 2nd Dec 2025 👉 biodtp.norwichresearchpark.ac.uk/projects/mak... Making Drugs Out of Sunlight and "Thin Air" ☀️🌿🧬⚗️ with secondary supervision from Prof. Anne Osbourn @johninnescentre.bsky.social 🥼 #SynBio #OrgChem #PhD
John Steele reposted
John Steele reposted
The proliferation of tools to generate predictive protein structures just underscores how important CASP is. There is no better way to allow unbiased & fair comparisons between tools! predictioncenter.org/index.cgi Such a shame NIH didn't renew funding
Apple is entering the protein folding arena. SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
John Steele reposted
Apple is entering the protein folding arena. SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
John Steele reposted
Ever wondered where your paracetamol comes from? Spoiler: crude oil. In this study – led by Nick Johnson from our lab in collaboration with @astra-zeneca.bsky.social – we show how biology and chemistry can work together to create a more sustainable alternative. (1/n) www.nature.com/articles/s41...
John Steele reposted
The Plant Shape Lab is hiring! Are you interested in supporting cutting edge cereal research? We are looking for an enthusiastic and dedicated technician to join us for 2 years, setting up and running cereal transformation. Find out more, and apply here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
John Steele reposted
📢Deadlines fast approaching for the BiPS Conference 2025! Join us for a day of connection and celebration where we'll be hearing from the renowned academics Nicola Patron and Kevin Cox. With workshops on a variety of topics and a chance for you to build your community. Register: buff.ly/J9PM0Wj
John Steele reposted
SULSA is running an Industry Academia conference on 28th & 29th October. Looks fantastic for researchers working in Scotland- particularly good for students interested in learning more about industry & working on skill development! sulsa.ac.uk/indac/
John Steele reposted
Food for thought here for anyone not working at TRUE atomic resolution…
Andreas Ehler et al.: A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding doi.org/10.1107/S205... #IUCr
John Steele reposted
If this is true, it’s abysmally shortsighted for #NIH. The new tools nurtured by the long series of #CASP challenges probably contribute far more in one year to the scientific and industrial economies than the entire funds that have supported it.
Exclusive: An international scientific competition widely credited with spurring the development of artificial intelligence for biology appears to be on its deathbed. scim.ag/44ukS90
John Steele reposted
Just learned that Frank Stahl (of the Meselson and Stahl DNA replication experiment ("the most beautiful experiment in biology") died at the beginning of April, to no fanfare. Here's a lovely video of them reminiscing: www.youtube.com/watch?v=7-tn...
John Steele reposted
Interested in trying out life as a scientific #editor? Based in the UK? Background in #PlantScience? The @plosbiology.org crew is expanding (again!), so a place in our lovely team might be for you...
I am recruiting - if you have a background in plant mol cell bio, a keen interest in sustainability and planetary health and are looking to move away from the bench, this may be for you! Have a 👀 and please reach out if Qs 1yr FTC, remote in the UK job-boards.eu.greenhouse.io/plos/jobs/46...
John Steele reposted
🧬 New toolkit for engineering Chlamydomonas plastomes! MoCloro brings Golden Gate modular cloning to algal chloroplasts — enabling fast, multigene integration & homoplasmy in 2 months 🌿 🔗 https://bit.ly/4jMNhfU #SyntheticBiology #Chlamydomonas #Microalgae #Plantscience
John Steele reposted
This is wild! Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol) www.nature.com/articles/s41... www.nature.com/articles/s41...
Always exciting when research from the lab is disseminated for the public! @theguardian.com have reported on @swallacelab.bsky.social paper turning plastic into paracetamol using engineered bacteria tinyurl.com/32hxnwsd (original publication rdcu.be/esYfF)
John Steele reposted