Lars Jansen Lab

Lars Jansen Lab

@jansenlab.bsky.social

Discovering Mechanisms of Chromatin Inheritance at the University of Oxford www.jansenlab.org

264 followers60 following13 posts

Just returned from an incredible 3-day multi-lab retreat with the teams of Daniele Fachinetti, Nick @naltemose.bsky.social, and Dominika Gruszka in P锚ra, Portugal. Sunshine馃槑, great company 馃 and fantastic centromere and chromatin science 馃敩! Thanks to all the teams for this wonderful gathering!

View full thread

We found that heterochromatin plays a key role in restricting the position of the CENP-A domain, ensuring only one CENP-A domain is nucleated per centromere. SUV39H1/2 and SETDB1 H3K9me3 methyltransferases differentially control neocentromeres, pericentromeric, and core alpha satellites.

SETDB1, previously implicated in transposon silencing, is a novel player in maintaining heterochromatin boundaries within core alpha satellites. This regulation is critical, as loss of heterochromatin integrity results in ectopic CENP-A domains and distal centromere nucleation!

Great Team! Check out the Gruszka lab position and apply!

馃毃 The Gruszka Lab is hiring! We鈥檙e looking for a Researcher in Microscopy Image Analysis to join our team. 馃敆 Know someone who might be interested? Share this post or tag them! 馃憠 Find out more and apply here: www.jobs.ac.uk/job/DNU476/r... @mplsoxford.bsky.social @oxfordphysics.bsky.social

Fresh of the press! rdcu.be/egmY0 We discovered key chromatin modifications that are heritably maintained through mitotic cell divisions in the absence of continued transcription. These hold a memory of past exposure to interferon-gamma, priming cells for future activation of gene expression.

You are up to date.