JAMA Neurology

📊 Among older adults, current smoking, #Hypertension, #Diabetes, chronic kidney disease, and history of stroke were associated with higher risk of #LateOnsetEpilepsy, indicating a link with underlying vascular disease. ja.ma/47o8t8v

Female sex, smoking, and family history were independent risk factors for de novo #IntracranialAneurysm formation after #AneurysmalSubarachnoidHemorrhage, and #SmokingCessation was associated with lower risk. ja.ma/3U4JTq2

In generalized #MyastheniaGravis, inebilizumab was associated with fewer exacerbations during corticosteroid tapering, including less use of intravenous immunoglobulin or plasma exchange. ja.ma/4hLfLI4

Among patients with #BranchAtheromatousDisease-related #IschemicStroke, intravenous #Tirofiban plus aspirin did not reduce early neurological deterioration or new stroke compared with aspirin alone. ja.ma/4zqUMl3

In preclinical #AlzheimerDisease screening, higher plasma phosphorylated tau 217 percentage was associated with higher amyloid #PET across racial groups. ja.ma/3VFP0xm

Among patients with relapsing #MultipleSclerosis, earlier and continuous ocrelizumab treatment was associated with better long-term relapse and disability control than delayed initiation after interferon beta-1a. ja.ma/3TOyWso

Among pediatric inpatients with unexplained #Neurologic presentations, rapid #WholeGenomeSequencing diagnosed nearly half of patients and changed management in about 2-thirds of diagnosed cases. ja.ma/4eqxDXI

Among patients with relapsing #MultipleSclerosis, earlier and continuous ocrelizumab treatment was associated with better long-term relapse and disability control than delayed initiation after interferon beta-1a. ja.ma/4yuFhZ7

Among patients evaluated for cognitive symptoms, earlier disclosure of blood-based biomarkers increased diagnostic certainty without worsening anxiety, depressive symptoms, perceived stress, or quality of life. ja.ma/4jcYyK5

💬 Editorial: In children with #NeurologicDisease, rapid #WholeGenomeSequencing may support earlier diagnosis and management changes, with increasing relevance as precision therapies emerge. ja.ma/4ASKaN8

Among pediatric inpatients with unexplained #Neurologic presentations, rapid #WholeGenomeSequencing diagnosed nearly half of patients and changed management in about 2-thirds of diagnosed cases. ja.ma/4AYIvWH

Can anesthesia choice during #stroketreatment affect recovery? #sedation #anesthesia 📌 Learn more: ja.ma/4hHLMll

In #MOGAD, MRI lesions often resolve over time and asymptomatic radiological activity is rare, limiting the clinical utility of surveillance MRI compared with multiple sclerosis. ja.ma/4ykzTrn

💬 Viewpoint: The role of #LeftAtrialAppendageClosure in #AtrialFibrillation may depend on patient phenotype, and more evidence is needed in patients who cannot take long-term direct oral anticoagulants. ja.ma/3TUWgVv

Among older adults with #MildCognitiveImpairment and hearing loss, hearing aid intervention did not significantly reduce dementia-level impairment over 24 months vs hearing care education. ja.ma/4yWDzzB

🧠 Portable low-field #MRI of the brain showed strong agreement with conventional MRI for key volumetric measures and may expand access to brain health assessment outside traditional radiology settings. ja.ma/3V77fvh

This case report describes 11.7-T in vivo human brain magnetic resonance imaging (MRI) of the basal ganglia in 2 healthy volunteers. ja.ma/4y89Tzq

📝 The #HINTS examination is most effective in patients with continuous dizziness and spontaneous nystagmus at rest. This Review indicates that outside this population , HINTS can reduce stroke diagnostic accuracy and lead to unnecessary imaging. ja.ma/4xDD7VV

📊🧠 A harmonized #TauPET visual reading framework for #AlzheimerDisease with five classes showed high agreement across raters and tracers, and identified more early-stage tau pathology than the regulatory-approved binary approach. ja.ma/4hiNHLV

📝 #Review from @jama.com: #Idiopathic normal pressure hydrocephalus is a progressive neurologic disorder in older adults associated with gait impairment and often urinary dysfunction and cognitive decline. 🔗 Learn more: ja.ma/3Tuhut6

Among patients with #BranchAtheromatousDisease-related #IschemicStroke, intravenous #Tirofiban plus aspirin did not reduce early neurological deterioration or new stroke compared with aspirin alone. ja.ma/4cYrWQ8

💬 Editorial: Among patients with #BranchAtheromatousDisease-related #IschemicStroke, the trial did not show an overall benefit of tirofiban plus aspirin. ja.ma/3UDTDrh

In 2 clinical trials, once-daily #tevapadon improved symptoms in patients with #ParkinsonDisease, increasing daily good on time in those taking levodopa and improving motor scores in early disease vs placebo. 📖 Read the full article to learn more: ja.ma/4xfuYYw

Female sex, smoking, and family history were independent risk factors for de novo #IntracranialAneurysm formation after #AneurysmalSubarachnoidHemorrhage, and #SmokingCessation was associated with lower risk. ja.ma/3Uwn12r

This JAMA Neurology #Review proposes #TDP43-associated neurodegenerative disease as a staging framework that links presymptomatic biology with later clinical phenotypes and could support earlier mechanism-based treatment development. ja.ma/4g487c8

This Review proposes #TDP43-associated neurodegenerative disease as a staging framework that links presymptomatic biology with later clinical phenotypes and could support earlier mechanism-based treatment development. ja.ma/4g487c8

Performance of the FDA-cleared Lumipulse plasma #biomarker for amyloid pathology detection in #AlzheimerDisease varied by site and reagent lots, highlighting need for local assay verification and ongoing quality control. ja.ma/4q6gHdO

Quantile aggregation may artificially inflate amyloid-cognition associations in #AlzheimerDisease trials, highlighting need for causally interpretable methods when assessing surrogate endpoints. ja.ma/4fXWkLf

Delayed onset of hemichorea and dystonia can occur after cortical temporal #Stroke, even when imaging reveals small acute ischemic lesions and routine blood tests are normal. ja.ma/4gk4fDW

#CavernousSinus dural arteriovenous fistula can present with proptosis, conjunctival injection, and ophthalmoplegia; endovascular embolization achieved complete occlusion and rapid symptom resolution in this case. ja.ma/4q1mUHU

📑 JAMA Neurology #Review: Gene delivery platforms for #Glioblastoma include viral vectors, lipid nanoparticles, and nanocarriers, with oncolytic HSV gaining approval and new nonviral approaches entering early clinical trials in #NeuroOncology. ja.ma/4fKjExd

For most patients with stroke and nonvalvular atrial fibrillation, anticoagulants alone remain the recommended treatment to prevent recurrence. Added therapies, like #aspirin or catheter ablation, may not provide benefit. #StrokePrevention 📖 Read full article to learn more: ja.ma/4zhyJxR

Integrating genetic and pathological data increased diagnostic accuracy and identified ancestry-related differences in #ParkinsonDisease, supporting biologically informed diagnostic tools and future pathology-targeted therapeutic trials. ja.ma/3RGAwvE

A reperfusion-guided systolic blood pressure strategy improved functional outcomes and reduced hemorrhagic transformation for patients with acute #Stroke after endovascular therapy compared with guideline-recommended management. ja.ma/4q8PO9g

Among patients with idiopathic #Myelopathy, screening for anti-CD320 antibodies with metabolic confirmation of central nervous system–restricted #VitaminB12 deficiency may help clarify diagnosis and guide treatment evaluation. ja.ma/4ic7a2O

Among adults with #Epilepsy receiving direct oral anticoagulants, antiseizure medication selection was associated with different risks of thromboembolic events, major bleeding, and all-cause mortality. ja.ma/4x3Dc5E

Among patients with familial or sporadic #FrontotemporalDementia, cerebrospinal fluid TMEM106B levels were lower with greater disease severity, progression, smaller brain volumes, and in carriers of the protective rs1990622 genotype. ja.ma/3THo4MJ

Among patients with acute ischemic stroke due to large-vessel occlusion, standard-dose tenecteplase resulted in greater early reperfusion vs low-dose alteplase, with comparable functional and safety outcomes. ja.ma/4fM3Xp9

Among veterans with prior #TraumaticBrainInjury, the plasma p-tau217/Aβ42 blood test for #AlzheimerDisease missed over half of brain amyloid-positive cases, indicating reduced diagnostic accuracy in this population. ja.ma/4x3cf2f

Randomized clinical trial indicates middle meningeal artery embolization with n-butyl cyanoacrylate plus standard care reduced #SubduralHematoma recurrence and need for surgery vs standard care alone, with comparable safety profile. ja.ma/4q0MJYA

Among adult #Ebola survivors, neurological symptoms such as memory loss, headaches, and depression remained common even 7 years post-infection, although most improved over time. ja.ma/4wRcoWd

Machine learning analysis of patient-clinician conversations identified cognitive impairment with sensitivity 68% and specificity 64%, supporting passive speech-based screening in routine #PrimaryCare. ja.ma/4xBpjvE

📝 A young adult with thoracic myelopathy developed worsening #SpasticParaparesis after lumbar puncture, and flexion #MRI revealed dynamic thoracic cord compression consistent with a Hirayama-like mechanism. ja.ma/4hmG74I

Among amyloid-positive individuals, a 7-protein plasma panel improved identification of advanced neocortical #tau pathology compared with phosphorylated tau-217 alone. ja.ma/4zowKbl

In generalized #MyastheniaGravis, inebilizumab was associated with fewer exacerbations during corticosteroid tapering, including less use of intravenous immunoglobulin or plasma exchange. ja.ma/4q2AY3Q

In #PrimaryProgressiveAphasia, automated #SpeechAnalysis of a brief picture description task distinguished nonfluent, logopenic, and semantic variants and produced interpretable speech profiles. ja.ma/4wRIH7y

In #MultipleSclerosis, higher serum glial fibrillary acidic protein was associated with greater risk of progression independent of relapse activity, while neurofilament light chain was more closely associated with relapse risk. ja.ma/3SlEudh

This case report describes a 60-year-old woman presenting with sudden loss of muscle tone with preserved consciousness and severe daytime sleepiness. ja.ma/4fMpmgB

In #PrimaryProgressiveAphasia, automated #SpeechAnalysis of a brief picture description task distinguished nonfluent, logopenic, and semantic variants and produced interpretable speech profiles. ja.ma/4w4A2xg

In #MultipleSclerosis, higher serum glial fibrillary acidic protein was associated with greater risk of progression independent of relapse activity, while neurofilament light chain was more closely associated with relapse risk. ja.ma/3TTRpU9