JAMA

🎙️JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, spoke with Rochelle P. Walensky, MD, MPH, about how differences in administrative burden, electronic health record use, and patient messaging could shape who benefits from artificial intelligence in practice.

Among patients with acute ischemic #Stroke who underwent successful #EndovascularTherapy for anterior circulation large vessel occlusion, adjunctive intra-arterial tenecteplase was associated with a higher rate of excellent functional outcome at 1 year vs standard medical treatment. ja.ma/47HX0Rm

📄 JAMA Patient Page: #HipFracture is a break in the upper part of the thigh bone near the hip joint and usually occurs after a fall. ja.ma/47LhTLh

Among patients with acute ischemic #Stroke who underwent successful #EndovascularTherapy for anterior circulation large vessel occlusion, adjunctive intra-arterial tenecteplase was associated with a higher rate of excellent functional outcome at 1 year vs standard medical treatment. ja.ma/47HX0Rm

If FDA follows a recent advisory cmte.’s advice, it will not only expose the public to the risks of unproven peptides but also threaten the integrity of the advisory cmte. system and the FDA’s drug approval process itself. Read my latest in @jama.com with Sophia Samantaroy, MS and Isabella Xu, MPH.

US #PrescriptionDrugs launch prices increased faster than inflation from 2008 to 2025, with no evidence of a higher postpassage trend after the #InflationReductionAct. ja.ma/4e4vcdr

📝 #JAMAReview: #Cancer vaccines are being evaluated for treatment and prevention across multiple malignant neoplasms as advances in tumor immunology, antigen discovery, and vaccine delivery reshape the field. 🔗 ja.ma/4srHHFL

💡 JAMA Insights: #AlcoholUseDisorder medications, including naltrexone, acamprosate, disulfiram, and topiramate, can support abstinence or reduced drinking and may be started in inpatient or primary care settings. ja.ma/4dWm76s

📊 Meta-analysis: In patients with cardiovascular disease, #HeartFailure, #ChronicKidneyDisease, or #diabetes, #SGLT2 inhibitors were associated with small increases in hemoglobin and hematocrit vs control. #KidneyWk @asnkidney.bsky.social ja.ma/4eLJwYo

💬 Editorial: #SGLT2 inhibitors consistently increase hemoglobin, an effect that may add to their cardiovascular and kidney benefits and may support anemia management in selected patients. ja.ma/4z6S4S3 #KidneyWk @asnkidney.bsky.social

What could slow health care spending growth? In a @jama.com Viewpoint, LDI Fellow @zekeemanuel.bsky.social outlines several approaches: AI, slower drug price growth, site-neutral payments, specialty value-based care models, and more. Read the Viewpoint here: https://bit.ly/4yuhEz0

For my @jama.com debut, @jsross119.bsky.social & I wrote a note contextualizing two new studies on opioid dispensing, naloxone use & overdoses. The lesson isn’t that one silver bullet succeeded but that effective OD prevention efforts must adapt to a dynamic epidemic. jamanetwork.com/journals/jam...

Some new patients now wait 6 to 10 months to see a primary care doctor. In my new @jama.com story, I dug into why. We're training too few PCPs in places that need them, making it harder for international doctors to stay, and underpaying the whole field. jamanetwork.com/journals/jam... #MedSky

Two new publications this week on opioid overdoses with David Zhu (VCU) and Travis Donahoe (Pitt). First, in @jama.com we explore whether or not trends in naloxone can explain what's happening with the decline in overdose deaths. It does not. jamanetwork.com/journals/jam...

#MedNews: #Testosterone use among women is rising, but does the evidence support it? A recent US FDA workshop brought new attention to the push for a testosterone product designed specifically for women.

#MedNews: Affecting an estimated 1.7 billion people worldwide, steatotic liver disease is emerging as an international public health issue. Read more:

In #ERBB2-low unresectable or metastatic #BreastCancer, trastuzumab rezetecan improved progression-free survival vs chemotherapy, with consistent benefit in both hormone receptor–positive and hormone receptor–negative disease. 📌 Learn more: ja.ma/4BoL3NT

📣 Presented at #KidneyWk: Among women with postdonation #Pregnancy after living #KidneyDonation, infants were more likely to be born small for gestational age vs infants in matched pregnancies among nondonors. ja.ma/3U9kZW9 @asnkidney.bsky.social

💬 Viewpoint: For well-appearing #FebrileInfants who meet modern low-risk criteria, routine #LumbarPuncture may offer little diagnostic yield and may add avoidable harm. ja.ma/4yrCxLv

Among assisted reproductive technology (#ART) modalities, intracytoplasmic sperm injection and frozen embryo transfer were associated with higher childhood cancer risk, while in vitro fertilization was not. ja.ma/4hW9KcR

After May 2023, EMS-documented nonfatal #drug overdoses and #opioid overdoses declined nationally, suggesting that fewer overdose events may have contributed to recent declines in overdose mortality. ja.ma/4BdlAH6

💬 Editor's Note: US #Opioid dispensing continued to decline through 2025, but the overdose epidemic has shifted toward illicit fentanyl, indicating that prescribing reductions alone are unlikely to explain recent mortality trends. ja.ma/4hQsLxm

From 2019 to 2025, #opioid dispensing in the US declined for overall prescriptions, morphine milligram equivalents per person, high-dose prescriptions, and extended-release or long-acting formulations. ja.ma/4jw7nyO

💡 JAMA Insights: For pediatric #MASLD, recommended treatment is dietary change and regular physical activity, and no drug therapy is currently approved for children or adolescents with this condition. ja.ma/4yzhIxA

📝 #JAMAReview: For childhood #Obesity, intensive health behavior and lifestyle treatment with ≥26 contact hours over 3 to 12 months is associated with reduced body mass index and improved cardiometabolic outcomes. ja.ma/47zgSG7

📌 Editor’s Choice from this week's issue of JAMA: ➡️ Normal Pressure #Hydrocephalus #Review, ➡️ Taking Multiple Meds Increased Among Older US Adults, ➡️ Long #COVID, and more. ja.ma/4zBggMa

Presented at #ANES26: Among high-risk patients undergoing elective major abdominal surgery, individualized #CardiacIndex-guided hemodynamic therapy did not reduce postoperative organ injury, severe infection, cardiac arrest, or death. ja.ma/4BycLrN

A recent JAMA Dermatology study that incorporated this design found that AI tools may help consumers better understand skin conditions. Accuracy was higher in the AI-based groups, with the Wizard of Oz group performing best. 📌 Listen to more: ja.ma/4AZYP9u

#MedNews: The US primary care shortage is deepening, leaving millions without timely access to care. What will it take to rebuild the workforce?

#MedNews: After the lipoprotein(a)-lowering agent pelacarsen failed to prevent major adverse cardiovascular events in a phase 3 trial, many are wondering what comes next.

In the latest episode of #HealthyDialogue, Mark Holmes, PhD, breaks down the #ruralhealth landscape in the US and discusses how the One Big Beautiful Bill Act and Rural Health Transformation Program could impact more than 60 million Americans. 📌Listen to full episode: ja.ma/4evWmtJ

Roy H. Perlis, MD, MSc will lead the JAMA Network's newest journal, dedicated to publishing clinically focused research spanning AI, computational health, digital health, and emerging technologies. 💡 Learn about his vision for the journal: ja.ma/4ySWXOv 📰 Read the press release: ja.ma/3TBDYZu

💬 Viewpoint: The US Food and Drug Administration authorization of over-the-counter hearing aids expanded legal access to hearing care, but regulatory reform alone has not ensured broad consumer benefit. ja.ma/4yPtMLY

In an editorial, Roy H. Perlis, MD, MSc, Annette Flanagin, RN, MA, and Kirsten Bibbins-Domingo, PhD, MD, MAS discuss the launch of JAMA AI, a new JAMA Network journal dedicated to publishing rigorous, clinically focused research spanning AI, digital health, and computational health. ja.ma/4s34h7m

Among US #clinicians, use of an #AI-enabled clinical information platform increased substantially over 2.5 years, with sustained use across #physician and nonphysician groups. ja.ma/4Ba9ej2

💬 Editor's Note: In the age of #ArtificialIntelligence, clinicians are increasingly using #AI-enabled #clinical information platforms to retrieve and apply #medical evidence at the point of care. ja.ma/481xKW1

Following a Department of War memorandum requiring annual testosterone screening for active-duty and reserve military personnel aged ≥30 years, a substantial proportion of male active-duty US Army personnel had a single morning #Testosterone value below screening thresholds. ja.ma/4jY9nzJ

💬 Perspective: The US Food and Drug Administration removed the boxed warning about cardiovascular risk from testosterone product labels after evidence indicated testosterone replacement therapy was noninferior to placebo for major adverse cardiovascular events. ja.ma/4yoCoZ5

💬 Viewpoint: In the era of #AI in #medicine, #physician training may need to emphasize bedside clinical skills, management reasoning, and critical appraisal rather than encyclopedic recall alone. jamanetwork.com/journals/jam...

💡 JAMA Insights: In the US, #Autopsy remains important for #PublicHealth surveillance, cause-of-death determination, and identification of diagnostic errors, treatment complications, and emerging disease patterns. ja.ma/47RhDKH