HDBuzz

With Huntington's disease (HD) it can be difficult to know when a new symptom is due to HD or something else - like catatonia, an uncommon condition that can cause changes that overlap with HD symptoms. Read more about recognizing catatonia alongside HD here → en.hdbuzz.net/blurred-line...

In Huntington’s disease, DNA repair proteins like MSH3 can sometimes accidentally make the CAG repeat grow longer over time, but targeting a tiny DNA-binding pocket on MSH3 slows this process, opening a new avenue for therapeutic development. Read the article here → en.hdbuzz.net/picking-msh3...

Huntington’s disease (HD) begins with a change in just one gene, huntingtin (HTT), but its effects spread throughout the body. So why are thousands of other genes disrupted in the HD brain? Pigs can help us solve this mystery. Read all about it here: en.hdbuzz.net/what-pigs-re...

Your cells are constantly mending tears and rips in the fabric of your DNA, like a cherished pair of jeans. Sometimes this adds extra lengths of C-A-G thread by mistake, but could other kinds of genetic mending also be involved in Huntington's? Full article here → en.hdbuzz.net/mending-the-...

Researchers set out to investigate whether changes in the activity of inhibitory neurons (the brain’s “brakes”) can help explain why movements become impaired in Huntington’s disease… and they discovered a striking pattern. Read all about it → en.hdbuzz.net/could-rewiri...

Speech analysis could be a simple, noninvasive way to monitor Huntington’s disease progression remotely, so HD researchers developed an AI-powered tool that analyzes a short counting task. #hdresearch Read all about it → en.hdbuzz.net/584-your-voi...

Getting “stuck” on a thought, action or conversation may not be stubbornness; it can be a symptom of Huntington’s disease (HD) called *perseveration*. Recognising perseveration as an HD symptom can improve understanding, support and care for affected families. en.hdbuzz.net/cant-get-you...

uniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful but complex results in this article → en.hdbuzz.net/amt-130-at-f...

September brought progress across the Huntington’s disease research landscape. From brain waves and visual thinking to DNA repeats, nutrition, inclusive care, new technologies, and encouraging SKY-0515 data, we round up a busy month in HD research. Full article here → en.hdbuzz.net/september-20...

The CAG repeat that causes Huntington’s disease (HD) has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome. #hdresearch Read the full article → en.hdbuzz.net/studying-stu...

Unique research highlights an overlooked mental health disparity among Indigenous North American people with Huntington’s disease (HD) - and the need for care grounded in trust, community partnership, and cultural understanding. Read more here: en.hdbuzz.net/highlighting...

Skyhawk Therapeutics shared data for SKY-0515, an experimental once-daily pill that targets both huntingtin and somatic instability, making it a possible “two-for-one” drug to treat HD. Read more about this exciting news on HDBuzz → en.hdbuzz.net/encouraging-...

What if nutrition is one of the warning lights we should be checking earlier in Huntington’s disease? New research suggests simple nutrition measures may help identify when people with HD need extra support. en.hdbuzz.net/food-for-tho...

A review of 23 studies suggests that EEG could offer a non-invasive way to track brain changes across the course of Huntington’s disease (HD). #hdresearch Read all about it → en.hdbuzz.net/could-brain-...

Five Huntington’s disease (HD) researchers discuss the cutting-edge techniques driving their work, accelerating discovery and guiding development of treatments. #hdresearch Read all about it → en.hdbuzz.net/hot-techniqu...

What if Huntington’s disease (HD) changes how we “see” the world before we even notice symptoms? New research suggests visual thinking skills may help track HD progression. en.hdbuzz.net/keeping-an-e...

NEWS! uniQure has submitted AMT-130 for regulatory approval in the US and UK. This drug is NOT yet approved; regulators must now review the evidence. Read more about this milestone here -> uniqure.gcs-web.com/node/12991/pdf and on HDBuzz here -> en.hdbuzz.net/the-other-sh...

August was a busy month for Huntington’s disease (HD) research! Setbacks, new trials, a conference, and the HDBuzz Prize for Young Science Writers! Catch up on everything in our monthly roundup: en.hdbuzz.net/august-2026-...

A new Huntington's disease (HD) clinical trial has officially begun! It will test whether the drug pridopidine can slow the progression of HD. For more details, read our article: en.hdbuzz.net/first-partic...

Rachel Harding & Leora Fox from @hdbuzzfeed.bsky.social will join us on 9/9 to share the buzz from HDF’s recent HD2026 Symposium. They'll recap some of the exciting science from the meeting and hold a live Q&A. Register Now: us06web.zoom.us/.../501.../W... #curehd #HD2026 #researchspotlightwebinars

If you've got stage 2 HD and want to do a science, here's a new Phase 1 study for a potential injectable therapy. They've got a cunning plan for getting treatments across the blood-brain barrier.

New research points to HTT1a, a toxic shortened form of huntingtin (HTT), as a key driver of disease and a promising therapeutic target in Huntington’s disease (HD). Read the full article here: en.hdbuzz.net/taking-a-sho...

New Huntington’s disease (HD) trial begins! A Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development quiver. More details here -> en.hdbuzz.net/a-shot-in-th...

Thanks, Leora Fox & Rachel Harding @hdbuzzfeed.bsky.social, for the excellent summary of my presentation at @hdfcures.bsky.social Meeting on the #HUNTIAM clinical trial (Thiamine+Biotin) for HD, including the evidence that originated it. 👇👇👇 en.hdbuzz.net/hd2026-milto... @cbm-csic-uam.bsky.social

Announcing the 2026 HDBuzz Prize for Young Science Writers – sponsored by the Hereditary Disease Foundation! Submission details here: en.hdbuzz.net/the-2026-hdb...

Day 3 of #HD2026 put the huntingtin protein (HTT) under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT might help. Read our roundup here: en.hdbuzz.net/hd2026-milto...