George Birchenough

Just in case any new #mucus, #Goblet cell or #mucin folks have joined up recently, we have a small but growing starter pack for this area - let me know if you want in 🫡 go.bsky.app/7Z84CmG

Microbiota colonising the new born colon prime goblet cells producing the gut-protective mucus 📷 Åsa Johansson et al @gobletcellguy.bsky.social University of Gothenburg in @jem.org ➡️ bpod.org.uk/archive/2025...

Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎

Abstract deadline for #GGIG2025 is approaching fast! Don’t miss your chance to share your research at the 5th Ghent Gut Inflammation Group Meeting! 🧬🦠 www.vibconferences.be/events/5th-g...

Which cells use Myd88 to control Segmented Filamentous Bacteria colonization? Here work explores the hematopoietic MyD88/IL-22 axis during SFB growth. www.mucosalimmunology.org/article/S193...

My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...

Nice discussion around the ongoing #glycoRNA debate, check out the comments

In our lates review, we explore new insights into the gut-joint axis, a connection is not absolute. A causal role for the microbiota is context-dependent, and arthritis can also arise independently through sterile mechanisms: authors.elsevier.com/a/1kkn55Eb0R... #GutJointAxis

Say what now?!

So excited to share this latest work by @kelseyhuus.bsky.social !!! She shows that flagellin in the human gut affects whether or not people develop fever in response to vaccine, and the amount of flagellin reflects diet

glycowork v1.5 is now released! We're excited to see the cool things you'll be doing with it:-) Lots of new & improved functionality, check out the Release notes for the full change log:

Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42... #metagenomics #microbiome #microbiomesky So what is MEDI? A combination of two things:

For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social #mucusmatters

1/ 🚨 New preprint alert! 🚨 We’re thrilled to share our latest work exploring microbiome & genomic #Bifidobacterium co-evolutionary & functional signatures across diverse animal hosts. This has been a long time coming, & huge credit to Magda for her incredible hard work as first author! 🐾✨👇

New paper out today from the lab on Akkermansia muciniphila 🦠and how it breaks down host glycans! Very proud of my group, especially @cassiebakshani.bsky.social who did an amazing job. @naturemicrobiol.bsky.social www.nature.com/articles/s41...

#microsky

Don’t miss #ASRI2025 in St. Paul Minnesota May 17-21. Check out fantastic talks on the Maternal, Fetal, and Neonatal Immunology and submit your abstract by 2/15! theasri.org/Abstracts-Po...

Still time to submit late breaking abstract to this fantastic meeting: www.perinatal-immunity.de/en/symposium...

The measles outbreak in Texas is reminding me of the public letter Roald Dahl wrote about losing his daughter to measles in 1962, just before the vaccine was publicly available.

Yes

Now that we're into #GPCR biology, I get to include (what I'm sure is) a very original joke in my journal club presentation...

How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells? 🧐 Using proximity labeling, proteomics, and CRISPR KO, we uncovered key roles for MYO1B, MYO5B, and SNX27 in mucin transport. portlandpress.com/biochemj/art... #mucins #glycotime

Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, which they degrade to completion, according to a Nature Microbiology paper. 🧪

Its stories like this that makes me incredibly excited! A gut immune–epithelial circuit regulating tolerance to food: Goblet cell protein RELMβ disrupts tolerance by depleting microbiome-derived indoles needed for protective Tregs. #microbiome #immunity #ImmunoSky www.nature.com/articles/s41...

Dear mucosal immunologists! Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open. Register and see you this July in Aachen! 👇🏼 emig2025.de @petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social

🎄 Santa came early this year!🎄 We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges. insight.jci.org/articles/vie... #mucins #glycotime #Crohns #gut

What are lumens and how do forces control tissue form and fate through lumen size? Join me, @dhirajindana.bsky.social, in this short thread to explore this question through some fascinating papers.

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

#Colorectal #Cancer #Starterpack. Patient Advocates, Scientists, Physicians, Institutes and Journals with a focus on Colorectal Cancer. Please comment/text to be added! go.bsky.app/PGqU6zP

#Medsky🧪 #oncosky The study found that aging suppresses tumorigenesis and stemness in 🫁 by promoting a functional iron insufficiency in the alveolar epithelium. via @TuomasTammela @xueqianzhang.bsky.social @naturecomms.bsky.social www.nature.com/articles/s41...

Very happy (and somewhat shocked) to have been awarded an #ERC #CoG grant to study how cervical #mucus prevents intrauterine infection and #preterm birth... looking forward to meeting a new mucosal community! (Watch this space for project linked job ads 🤩)

Holy smoke—James Saenz @jamessaenz.bsky.social goes full Marie Kondo on Mycoplasma mycoides and eliminates all but two lipids from its membrane. And of course, one of them is cholesterol! 😅 The other one is a sneaky diether lipid which M. mycoides cannot remodel. Cool!!! rdcu.be/d1Uff

Happy to see our latest preprint shared on Bluesky! Check it out if you're interested in how the colons #mucus barrier system develops in newborn mice

#mucus #gobletcell #mucin starterpack now up and running! It's a short list so far so please let me know if you want to be added to it 🦠 go.bsky.app/7Z84CmG

Do we need a #mucus #mucin #gobletcell starter pack? Guess it could be quite small... Thoughts @mucusman.bsky.social @mucubacter.bsky.social @tpelaseyed.bsky.social ?

By popular demand @science.org is on Bluesky!! No posts until after Thanksgiving, but stand by! @karaestellepowers.bsky.social @kakape.bsky.social @jakeyeston.bsky.social

🌟 Exciting News! 🌟 The Society for Mucosal Immunology is now on Bluesky! Join us as we continue advancing mucosal immunology with engaging discussions, research highlights, and community updates. 🌍🔬 👉 Find us here: socmucimm.org @mucosalimmunol.bsky.social #MucosalImmunology #ScienceCommunity

Happy weekend everyone! So great to see how this sunny space is growing!🦋 We are working on the interaction between #diet, #gutmicrobiota 🦠🧫and #mucus in health and disease: www.mucubacter.org. Happy to connect! #MicrobiomeSky #MicroSky #GIsky #IBD #GIresearch #microbiome

🎵"It's just another #MucusMonday" Alcian blue staining of (abnormal) mucus secretion (blue) filling the colonic lumen. 🧪 🧫 🔬 🦠

COVID-19 hitches a ride on mucus to spread deep into lungs, live imaging shows. Study: www.nature.com/articles/s41... Source: archive.md/VSzDS

Seems that @biorxivpreprint.bsky.social ought to consider adding links to @bsky.app posts given the mass transfer of scientists from Twitter to @bsky.app that is taking place.