Glennis Logsdon

Glennis Logsdon

@glennislogsdon.bsky.social

Assistant Professor of Genetics and Core Member of the Epigenetics Institute at UPenn | T2T, HPRC, and HGSVC member | Loves genomics, epigenomics, and synthetic biology | logsdonlab.com

659 followers62 following8 posts

Glennis Logsdon reposted

Bungo Akiyoshi
@bungoakiyoshi.bsky.social

The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access) link.springer.com/collections/...

link.springer.com40 years of CENP-AIn 1985, Earnshaw and Rothfield published in Chromosoma a landmark discovery of the centromere-specific protein CENP-A. Subsequent research has shown that ...
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Glennis Logsdon
@glennislogsdon.bsky.social

Our work reveals an "arms race" between centromeric sequences and proteins, with frequent mutations within the site of the kinetochore that lead to changes in genetic and epigenetic landscapes and, ultimately, rapid evolution of these critically important regions.

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Glennis Logsdon
@glennislogsdon.bsky.social

Finally, comparison with 6,230 centromeres assembled by the HPRC and a 4-generation pedigree (8,340 centromeres total) reveals that centromeres vary in mutation rate by >50-fold. Surprisingly, the kinetochore site is often the most rapidly mutating region in the centromere.

Glennis Logsdon
@glennislogsdon.bsky.social

We find that the location of the kinetochore depends on the underlying sequence and structure of the centromere, with some chromosomes having a single kinetochore location and others having multiple, distinct locations that stratify by haplotype structure.

Glennis Logsdon reposted

UC Santa Cruz Genomics Institute
@ucscgenomics.bsky.social

It's exciting to see the continuing legacy of T2T sequencing methods being discussed on @scifri.bsky.social ! 🧬 Complete genomes are helping us understand more and more about genetic function and diversity in areas of our DNA that were unreadable just a few years ago.

Adam Phillippy@aphillippy.bsky.social

Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes" 📄 www.nature.com/articles/s41... 📻 www.sciencefriday.com/segments/65-...

sciencefriday.com65 Genomes Expand Our Picture Of Human GeneticsResearchers closely examined the genomes of 65 individuals to paint a more complex, and more complete, picture of human genetic diversity.

Glennis Logsdon reposted

Christine Beck
@christinebeck.bsky.social

This was both fun and terrifying to tape! Awesome to talk with @glennislogsdon.bsky.social and @aphillippy.bsky.social about our sequencing data / paper, the improvements to large-scale sequencing projects, and what this means for our understanding of our DNA!

Adam Phillippy@aphillippy.bsky.social

Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes" 📄 www.nature.com/articles/s41... 📻 www.sciencefriday.com/segments/65-...

sciencefriday.com65 Genomes Expand Our Picture Of Human GeneticsResearchers closely examined the genomes of 65 individuals to paint a more complex, and more complete, picture of human genetic diversity.

Glennis Logsdon reposted

Adam Phillippy
@aphillippy.bsky.social

Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes" 📄 www.nature.com/articles/s41... 📻 www.sciencefriday.com/segments/65-...

sciencefriday.com65 Genomes Expand Our Picture Of Human GeneticsResearchers closely examined the genomes of 65 individuals to paint a more complex, and more complete, picture of human genetic diversity.

Glennis Logsdon reposted

Simon Fisher
@profsimonfisher.bsky.social

Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪

nature.comComplex genetic variation in nearly complete human genomes - NatureUsing sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

Glennis Logsdon reposted

Yuichi Shiraishi
@friend1ws.bsky.social

🚨New preprint out! 🧬Short reads can now decode centromeres. 🌍We reveal population-scale centromere haplogroups and their links to disease. biorxiv.org/content/10.1... (1/n)

biorxiv.orgRare k-mers reveal centromere haplogroups underlying human diversity and cancer translocationsCentromeres are among the most diverse and dynamically evolving regions of the human genome and are commonly affected in various human cancers. However, organized into highly repetitive α-satellite hi...

Glennis Logsdon reposted

Adam Phillippy
@aphillippy.bsky.social

ModDotPlot preprint is now out! Winner of best poster at RECOMB 2023, it can generate either static or interactive dotplots in minutes using hierarchical modimizers. With @alexsweeten.bsky.social and @mikeschatz.bsky.social Preprint: www.biorxiv.org/content/10.1... Code: github.com/marbl/ModDot...

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Glennis Logsdon reposted

Adam Phillippy
@aphillippy.bsky.social

We demonstrate a single-platform solution for complete T2T genomes on the ONT PromethION: Duplex + Ultra-long + Pore-C, aka "TNT" 🧨 Expecting rapid improvements in the coming year. Congrats @sergek.bsky.social @zbao.bsky.social @awngs.bsky.social @awngs.bsky.social @khmiga.bsky.social et al.!

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social

Gapless assembly of complete human and plant chromosomes using only nanopore sequencing https://www.biorxiv.org/content/10.1101/2024.03.15.585294v1

biorxiv.orgGapless assembly of complete human and plant chromosomes using only nanopore sequencing https://www.biorxiv.org/content/10.1101/2024.03.15.585294v1 The combination of ultra-long Oxford Nanopore (ONT) sequencing reads with long, accurate PacBio HiFi

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