Fabian Streit

Fabian Streit

@fstreit.bsky.social

psychologist|@zi_mannheim|psychiatric genetics|stress depression pgc.unc.edu/for-researchers/working-groups/mdd personality disorders https://zi-mannheim.de/pdgg german national cohort nako.de/en/research/expert-groups/neurological-and-psychiatric-diseases

207 followers349 following34 posts

Fabian Streit reposted

Brock Kirwan
@brockkirwan.com

In honor of International Left-Handers Day, we have an updated preprint on scanning left-handed participants in fMRI studies. Although they're 11% of the population, we routinely screen LH people out of fMRI studies due to concerns about functional lateralization 1/n www.biorxiv.org/content/10.1...

biorxiv.orgLeft Out: The Effect of Handedness on fMRI Activation in Memory ParadigmsAbout 11% of the population is left-handed, a significant minority of the potential participant pool for functional MRI (fMRI) studies. However, convention in fMRI research dictates these potential pa...
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Fabian Streit
@fstreit.bsky.social

It was a pleasure to work with Swapnil Awasthi, Stephanie Witt, Stephan Ripke, and Marcella Rietschel, who co-led the study, as well as all our other collaborators! Thanks also to all the funders who supported this research! 7/7

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Fabian Streit
@fstreit.bsky.social

• We identify the first genetic risk loci and genes associated with BPD. • The genetic signal shows strong correlations with other mental disorders, particularly PTSD, depression, and ADHD. We also observe shared genetic risk with physical health traits, although to a lesser extent. 4/7

Fabian Streit
@fstreit.bsky.social

• We find genetic links with continuous traits, including neuroticism, agreeableness, and conscientiousness. • The derived polygenic scores can serve as a powerful research tool. They explain 4.6% of case-control status on the liability scale and show a broad range of associations in PheWAS. 5/7

Fabian Streit
@fstreit.bsky.social

Twin and family studies of BPD indicate that, besides the well-established influence of environmental factors such as interpersonal trauma, genetic factors make a substantial contribution to liability for BPD. However, relatively little work has been done to pinpoint specific genetic variants. 2/7

Fabian Streit
@fstreit.bsky.social

We aimed to change this by analyzing genetic data from more than 13,000 BPD cases and over 1,000,000 controls in a GWAS meta-analysis. Some of the main findings: • Like other mental disorders, BPD is highly polygenic. We estimate its SNP-based heritability at approximately 17%. 3/7

Fabian Streit reposted

Science X / Phys.org
@sciencex.bsky.social

The largest genetic analysis of borderline personality disorder identified 11 independent risk regions and nine candidate genes, using data from about 13,000 affected people and 1.1 million controls. doi.org/hcb6qq

medicalxpress.comLargest genetic analysis of borderline personality disorder identifies 11 risk regions and nine genesAn international team led by the Central Institute of Mental Health in Mannheim has presented the largest genome-wide association study on borderline personality disorder to date.

Fabian Streit reposted

Scott McGrath
@smcgrath.phd

🧪 Data from 12,339 people with borderline personality disorder powered the largest GWAS for the condition so far. They mapped 11 associated genomic locations, explaining about 17% of inherited risk. The strongest genetic correlation they found was with PTSD. 🧬💻

nature.comHuge study finds first genetic clues for borderline personality disorderLargest genetic analysis of the condition so far finds 11 linked locations in the human genome.

Fabian Streit reposted

Aysu Okbay
@aysuo.bsky.social

Come work with me and @dr-appie.bsky.social in Amsterdam!

Abdel Abdellaoui@dr-appie.bsky.social

Me & @aysuo.bsky.social are hiring a postdoc to study gene–environment interplay in health & social inequalities 🧬 You'll analyze genomic data as part of a collaboration with Uppsala & Oslo at @amsterdamumc.bsky.social (NL) werkenbij.amsterdamumc.org/en/vacatures... Please RT for karma points ♥️

werkenbij.amsterdamumc.orgVacatures - Postdoctoral researcher specialising in gene–environment interplay - Amsterdam UMCReady to unravel the complex interplay between genes and environment shaping health and society? Join our interdisciplinary team analyzing large-scale genomic data across Europe. Are you eager to contribute to groundbreaking research on health and social inequalities?

Fabian Streit reposted

PsyGenOmics
@psygenomics.bsky.social

New report by the PGC outreach committee: From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics (2026) An important contribution on why dialogue, and responsible communication must be integral to psychiatric genetics. link.springer.com/article/10.1...

link.springer.comFrom Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics - Behavior GeneticsOutreach in psychiatric genetics bridges the gaps across research advancements, clinical practice, and public understanding. Effective communication with a range of audiences faces multiple challenges...
Fabian Streit
@fstreit.bsky.social

These findings are based on cross-sectional data, and childhood maltreatment was reported retrospectively, which may introduce recall or reporting bias. Causal interpretations should therefore be made with caution.

Fabian Streit
@fstreit.bsky.social

We thank all participants of the @nako.de and the many researchers and staff involved. Special thanks to Aina Kresken and Maja Völker, who led the analyses as part of their Master’s and PhD work 👏

Fabian Streit
@fstreit.bsky.social

We estimated population attributable fractions (PAFs) to quantify the contribution. Overall, maltreatment accounted for 26% of lifetime depression and 33% of current depression, with consistently higher contributions in females. Emotional abuse and emotional neglect showed the largest contributions.

Fabian Streit
@fstreit.bsky.social

Mediation analyses including all five childhood maltreatment subtypes jointly, showed that childhood maltreatment mediated ~19% of the sex difference in lifetime depression and ~30% of the sex difference in current depression, mainly due to sex differences in exposure.

Fabian Streit
@fstreit.bsky.social

We examined five types of childhood maltreatment. Females reported higher prevalence of sexual abuse, emotional abuse, and emotional neglect, with the strongest sex difference for sexual abuse (~9.5% vs 2.5%). Physical abuse was slightly more common in males (~8.3% vs 7.7%).

Fabian Streit
@fstreit.bsky.social

For lifetime depression (physician’s diagnosis), physical abuse and physical neglect showed stronger associations in females, whereas sexual abuse showed a stronger association in males. All maltreatment subtypes were associated with substantially increased odds of depression in both sexes.

Fabian Streit
@fstreit.bsky.social

We analyzed data from 159,045 participants aged 19–72 years from the German National Cohort. Both lifetime depression (physician’s diagnosis) and current depression (PHQ-9 ≥ 10) were more common in females than in males (17.7% vs 10.1% and 9.0% vs 5.9%, respectively).

Fabian Streit reposted

Michael Dufner
@michduf.bsky.social

New paper out: Some people are systematically better at judging others’ intelligence. Who are the best judges? People WHO are intelligent themselves, have good emotion-perception ability, and who are high in well-being. www.sciencedirect.com/science/arti...

sciencedirect.comThe good judge of intelligenceAccurately judging others' intelligence is important, yet little is known about individual differences in this ability. In this study we investigated …
Fabian Streit
@fstreit.bsky.social

Happy to share this: we confirmed a significant link between smoking and depression using data from the @nako.de. Our analysis of over 170,000 participants shows that both current and former smokers face a higher lifetime risk of depression. #MentalHealth #ResearchNews #PublicHealth

NAKO Gesundheitsstudie (German National Cohort)@nako.de

Scientists showed that depression was more common among current and former smokers than among never-smokers over the course of their lifetime. In addition, a dose-response relationship was observed. 👉 nako.de/en/press-rel...

nako.deNAKO study confirms link between smoking and depression – German National Cohort (NAKO)A research group led by the Central Institute of Mental Health (CIMH) in Mannheim has confirmed for the first time within the German National Cohort (NAKO) an association between cigarette consumption...
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Fabian Streit
@fstreit.bsky.social

We observed a clear dose-response relationship: higher daily cigarette consumption correlates with more severe depressive symptoms, while the risk decreases the longer an individual has remained abstinent.

Fabian Streit
@fstreit.bsky.social

I want to thank all researchers involved, including Maja Völker, Carolin Callies, and Stephanie Witt, and all the staff and participants of @nako.de. Looking forward to extend this investigation to the longditudinal data available now, and to other data domains including MRI and genetics!

Fabian Streit
@fstreit.bsky.social

Happy to share this: we confirmed a significant link between smoking and depression using data from the @nako.de. Our analysis of over 170,000 participants shows that both current and former smokers face a higher lifetime risk of depression. #MentalHealth #ResearchNews #PublicHealth

NAKO Gesundheitsstudie (German National Cohort)@nako.de

Scientists showed that depression was more common among current and former smokers than among never-smokers over the course of their lifetime. In addition, a dose-response relationship was observed. 👉 nako.de/en/press-rel...

nako.deNAKO study confirms link between smoking and depression – German National Cohort (NAKO)A research group led by the Central Institute of Mental Health (CIMH) in Mannheim has confirmed for the first time within the German National Cohort (NAKO) an association between cigarette consumption...

Fabian Streit reposted

Science X / Phys.org
@sciencex.bsky.social

Analysis of over 170,000 adults indicates that current and former smokers experience depression more frequently than never-smokers, with risk decreasing the longer a person has quit smoking. doi.org/hbk2gw

medicalxpress.comLink between smoking and depression confirmed in studyA research group led by the Central Institute of Mental Health (CIMH) in Mannheim has confirmed for the first time within the German National Cohort (NAKO) an association between cigarette consumption and depression.

Fabian Streit reposted

Michel Nivard
@michelnivard.bsky.social

A very comprehensive review of the genetics of personlity led by @tedmond.bsky.social This is a great onramp for those who haven't checked into psychiatric genetics or bahviour genetics in a while. www.annualreviews.org/content/jour...

annualreviews.orgPersonality GenomicsRecent research advances have precipitated the era of personality genomics: the study of how variation in human DNA sequence predicts individual differences in characteristic patterns of thinking, fee...

Fabian Streit reposted

Michel Nivard
@michelnivard.bsky.social

This is an interesting challenge, Its A LOT of data for psychology, but not for ML perse. I wonder whether there is juice to be squeezed out of other EMA data, which would only have partial feature overlap, loads of other EMA data lives here: openesmdata.org.

openesmdata.orgOpenESM: Open Experience Sampling Method Database<!DOCTYPE html> OpenESM: Open Experience Sampling Method Database A database of open experience sampling datasets openESM is a database of harmonized openly available experience sampling datasets. The...
Eiko Fried@eikofried.bsky.social

After 5 years of data collection, our WARN-D machine learning competition to forecast depression onset is now LIVE! We hope many of you will participate—we have incredibly rich data. If you share a single thing of my lab this year, please make it this competition. eiko-fried.com/warn-d-machi...

eiko-fried.comWARN-D machine learning competition is live » Eiko FriedIf you share one single thing of our team in 2026—on social media or per email with your colleagues—please let it be this machine learning competition. It was half a decade of work to get here, especi...

Fabian Streit reposted

Sarah Colbert
@sarahcolbert.bsky.social

🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct. www.medrxiv.org/content/10.1...

medrxiv.orgGenome-wide association studies identify 77 loci for suicidality and provide novel biological insightsSuicidality is heritable and a leading cause of global morbidity and mortality, yet its biological etiology remains largely elusive. We conducted multi-ancestry genome-wide association study meta-anal...

Fabian Streit reposted

Philippe Jawinski
@pjawinski.bsky.social

🧠 Why do some brains age faster than others? 🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age. nature.com/articles/s43587-025-00962-7 Thread below 👇

nature.comGenome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature AgingThis genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type 2 diabetes as causal factors of brain aging.

Fabian Streit reposted

Jonathan Sebat
@sebatlab.bsky.social

The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits

medRxivpreprint@medrxivpreprint.bsky.social

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits https://www.medrxiv.org/content/10.1101/2025.07.11.25331310v1

Fabian Streit reposted

DurstewitzLab
@durstewitzlab.bsky.social

Got prov. approval for 2 major grants in Neuro-AI & Dynamical Systems Reconstruction, on learning & inference in non-stationary environments, out-of-domain generalization, and DS foundation models. To all AI/math/DS enthusiasts: Expect job announcements (PhD/PostDoc) soon! Feel free to get in touch.

Fabian Streit reposted

Iiris Hovatta
@iirishovatta.bsky.social

I’m excited to share our genetic study on panic disorder in the FinnGen sample. We found a genomewide significant hit within the SORCS3 gene and showed that SORCS3 serum protein levels were 40% higher in panic disorder patients compared to controls medrxiv.org/cgi/content/...

medrxiv.orgGenome-wide Association Study Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen StudyPanic disorder is an anxiety disorder with poorly understood etiology. Although twin studies suggest modest heritability (∼40%), few genetic variants have been associated with it. We carried out a gen...
Fabian Streit
@fstreit.bsky.social

Great to see this paper finally online, and happy we could contribute (a bit) to it! It's a big progress in regard to variant discovery (especially for the other 4 Big 5) but Ted and team also ran a wide range of super interesting follow-up analyses, that showcase the potential of the results. 🥳🧬

Ted Schwaba@tedmond.bsky.social

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...