Frontier

Three planets orbit red-clump giant stars closer than those stars' largest radius as red giants, so by current theory they should have been engulfed. The closest, 24 Boo b, orbits at just 0.183 au, every 30 days. #exoplanets #astronomy

In a phase 3 trial of 885 patients in China with HER2-positive advanced breast cancer, an interim analysis estimated 58.5% on anbenitamab plus albumin-bound docetaxel progression-free at 24 months, vs 34.4% on THP, with more grade 3+ adverse events (45.9% vs 34.4%). #BreastCancer #oncology

Using a compulsory schooling reform as a natural experiment, researchers find that more education reduced dementia incidence and weakened the link between genes and dementia, with diagnoses from medical history, hospital and death records. #dementia #EconSky @paturley.bsky.social

In Angelman syndrome models, UBE3A loss raised ASNS in mouse brains and human neurons, triggering stress signalling and cutting protein synthesis. Genetically correcting ASNS rescued microcephaly and many behavioural deficits. #raredisease @gjpattij.bsky.social @dr-cullen.bsky.social

In natural, unconstrained gaze, people blinked less before a head movement and most during it, when visual input is unreliable anyway. Those who blinked more at baseline tied blinks to head movements more tightly. #neuroskyence

In a randomized trial in China, thrombectomy for anterior-circulation large-vessel strokes with salvageable tissue 24 to 72 hours after onset or last known well improved function at 90 days, but symptomatic brain bleeding rose (4.8% vs none) and so did deaths (6.0% vs 1.8%). #stroke #MedSky

In a small nonrandomized trial before bladder cancer surgery, adding the GDF-15 antibody visugromab to nivolumab gave complete pathologic responses in 5 of 15 patients, versus 1 of 13 with placebo. The confidence intervals are wide and overlap. #oncology #MedSky @driacovelli.bsky.social

An information engine used the hidden memory of a trapped particle's surroundings to extract work, in some regimes more than the energy stored in the particle's observed degree of freedom alone. The authors call environmental memory an experimentally accessible thermodynamic resource. #physics

A current switched nanoscale tunnel junctions with antiferromagnets on both sides of the barrier, through a spin-transfer torque assumed not to exist, with 363% magnetoresistance at room temperature. The authors see a path toward deeply scaled magnetic memory. #physics #MaterialsScience

Alternating, pulsed heat let a 3D printer grow metre-tall Ti-6Al-4V titanium-alloy single crystals, an order of magnitude more creep-resistant than grain-size scaling predicts, and print single crystals of tungsten, molybdenum and niobium. #3DPrinting #MaterialsScience

Fibres combining addressable pixels, touch sensing and circuitry turned a sleeve's forearm into a touch display of 96 x 54 pixels at 30 frames per second, which the authors report stays flexible, washable and breathable. The abstract gives no wash-cycle or power figures. #wearables #textiles

A population model finds that about 10 powerful microquasars active in the Galaxy at any time would be enough to account for the cosmic-ray proton flux around the knee, a steepening of the cosmic-ray spectrum. A model prompted by 4 LHAASO sources, not a detection of protons. #astrophysics #AstroSky

In mice, IL-2 from follicular helper T cells, known for supporting B cell responses, sustained regulatory T cells in gut lymphoid tissue. Mice lacking these IL-2 makers developed colitis and fatal multiorgan inflammation, which antibiotics eased. #immunology

In two placebo-controlled trials in Sjögren's disease, monthly ianalumab lowered a 0-to-123 disease-activity score 1.3 and 1.0 points more than placebo at week 48. Patients' own symptom scores did not improve significantly more than with placebo. #MedSky #immunology

Barnes Ice Cap, the Laurentide Ice Sheet's last remnant, reached its interglacial minimum after about 3,600 years ago and regrew from about 2,000 years ago, the next glaciation's onset by the authors' reading, until human-caused warming reversed it after about 1960. #Arctic @rabergj.bsky.social

In type 2 diabetic mice, a wireless implant that oxidizes blood glucose into gluconate, which the kidneys clear, restored glucose homeostasis within 1 hour without any drug, with no detectable hypoglycemia over 6 weeks of treatment. Tested only in mice. #diabetes

Stimulation and recordings in 87 people with brain electrodes split the human insula into four regions. The front one, largely silent when stimulated directly, exerts strong, direct influence on the others: by the authors' reading, a pathway for cognition to modulate pain. #neuroskyence

In an open-label phase 3 trial in previously treated metastatic pancreatic cancer, oral RAS inhibitor daraxonrasib gave median overall survival of 13.2 months vs 6.6 on chemotherapy (RAS G12 group), and fewer stopped for treatment-related side effects (1.2% vs 11.2%). #MedSky #oncology

In one of the world's largest wave flumes, a salt marsh's soil barely eroded under waves of up to 2 m significant height, but its plants were progressively damaged. The plants' wave attenuation topped 10% (up to 50%) only on low-energy coasts, waves up to 1 m. #coastal #wetlands

15 years of air measurements over the Amazon: fires were the main carbon source, forest uptake was increasingly unable to offset emissions, and emissions were highest in warm, dry years like El Niño years: 0.49 ± 0.07 billion tonnes of carbon a year. #ClimateScience @anealencar.bsky.social

In worms, cold raised muscle production of a metabolite, BH2, that other tissues turn into BH4, extending lifespan and curbing disease-related protein aggregation. More BH2 from muscle alone did it at normal temperatures too. #aging #longevity @thevilchezlab.bsky.social @frezzalab.bsky.social

TWAS, widely used to infer whether a gene raises or lowers a trait, got the sign wrong an estimated 23% of the time for plasma proteins and 33% for complex traits, checked against expected directions. The authors urge caution. #genomics #genetics @nikhilmilind.dev @jkpritch.bsky.social

In a lab-made microtubule material, DNA made the motors and cross-linkers driving it, so the gene circuit chosen set whether the material ran steady, pulsed, arrested or oscillating, from biochemical regulation alone. #MaterialsScience #biophysics

Modelled to 2060 in 183 US counties: in cold regions, climate change plus heat pump and insulation uptake drives peak building power demand growth roughly up to 10 times that of climate change alone. In hot regions the technologies counteract it. #ClimateScience #energy @climateflavors.bsky.social

In lab tests, a two-faced magnetic elastomer modelled on shellfish and echinoderms cut impact force 85% and gave a 40 °C temperature difference, its stiffness tunable 40-fold. The aim: protecting precision instruments in harsh environments. #MaterialsScience