Franze Lab

Check out 2 papers and a related Perspective on tissue regeneration in @science.org this week Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration | Science www.science.org/doi/10.1126/...

Thanks a lot for your kind words, Mekayla. This is really an amazing study, glad we could contribute a small bit to it. Congrats again to the whole team!!

We are hiring!

Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...

As every year, we had an exciting practical at @pdncambridge.bsky.social where vet students are shown how to handle reptiles. Big thanks to #AmazingReptiles !!

Let's get this hashtag started! The 2026 Santa Cruz Developmental Biology Meeting is happen this August! We will share updates using #SCDB26. Can't wait! scdb2026.sites.ucsc.edu

Very excited that the lab's first paper is out! We showed that in stem cells, Aurora B controls abscission dynamics by regulating microtubules stability and MCAK recruitment. Very happy with this streamlined version of our 2024 preprint. www.cell.com/cell-reports...

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

Excited to share this new work from Ana Raffaelli, in collaboration with Ewa Paluch's lab and involving several of my colleagues at Cyclana Bio. In this paper, we show that basement membrane mechanics instructs developmental signalling and fate patterning. www.biorxiv.org/content/10.6...

🚨 New Preprint from the Paluch & Chalut Labs 🚨 Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire #mechanobiology #hESCs #substratemechanics doi.org/10.64898/202...

During #brain development, axons grow along precise pathways. Scientists have now discovered that tissue stiffness & chemical signalling interact with each other. 👉 mpzpm.mpg.de/news/news-de... @fau.de @embl.org @franzelab.bsky.social #research #neuroscience

Presenting our latest results!! Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!! #xenopus #mechanobiology

#Frogpower here

Very excited to share our latest work on the interplay between chemical and mechanical signals orchestrating brain development 🧠⚙️! This was a great team effort and I am grateful to have been a part of it!! @evapillai.bsky.social @sudimukherjee.bsky.social @franzelab.bsky.social

🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders? Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing 🔗 www.biorxiv.org/content/10.1... Happy New Year, everyone! 🎉 🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇

You fully deserve it! Just continue your amazing research at the interface of physical and life sciences. very much looking forward to future breakthroughs coming from your lab! Congrats, Elias!

Congrats, Eva!

Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity. My main postdoc paper is finally online! Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab. @franzelab.bsky.social www.nature.com/articles/s41...

Great lab, highly recommended! And, even if I may be a bit biased, also the environment is pretty cool. #mechanobiology @mpi-scienceoflight.bsky.social (MPZPM)

If you're interested in a fully funded PhD position in an amazing lab in the UK working at the interface of life and physical sciences, go for it! Warwick offers a vibrant scientific environment with a strong biophysics community. And Eva is just a great scientist and person!

Thank you Dionn Hargreaves, Sarah Woolner & @dev-journal.bsky.social for highlighting our @sudimukherjee.bsky.social @franzelab.bsky.social preprint! Chuffed to see it engaged with through fresh eyes! 🙌 Interested in how mechanical & chemical signals shape tissue development? Give it a look! 🧠🐸⚙️

Thanks for picking our preprint and for this very nice prelight article!

Thanks a lot to @dev-journal.bsky.social and the Woolner lab for highlighting our recent preprint investigating how long-range chemical signals are regulated by tissue mechanics. journals.biologists.com/dev/article/...

Excited to announce the Molecular Biology of Archaea (MBoA) 2026! Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.

Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41...

We are really proud to share the first 'Pre-Print' from the Storer lab driven by the fantastic Byron Mui, and co-lead by the innovative Kevin Chalut, on tissue mechanics, ECM and regeneration. A big thanks also to our collaborators in the Franze Lab. www.biorxiv.org/content/10.1...

Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you. go.bsky.app/G5cQqYT