Jess Ewald

Jess Ewald

@ewaldlab.org

Computational biologist using omics data (imaging, gene expression) to investigate the impacts of environmental contaminants on biological systems Group Leader @EMBL-EBI (www.ewaldlab.org)

2K followers1.8K following21 posts

Jess Ewald
@ewaldlab.org

It's been a great first few months at the EBI!

EMBL-EBI@ebi.embl.org

Meet our newest Research Group Leader: Jess Ewald @ewaldlab.org ‬🇨🇦 Jess’s group takes a multi-disciplinary approach to identify and characterise chemical hazards to humans and ecosystems, using cell profiling data, machine learning, and integrative data analysis. www.ebi.ac.uk/about/news/p... 🖥️🧬

ebi.ac.ukWelcome: Jess EwaldJess Ewald, Research Group Leader at EMBL-EBI, uses cell profiling and AI to find and characterise chemical hazards to humans and ecosysystems.

Jess Ewald reposted

Niranj Chandrasekaran
@niranjchandrasekaran.com

Morph Map is now published in Nature Methods. Excited to see what the community discovers with this resource mapping ~15,000 human genes! rdcu.be/ezGre

rdcu.beMorphological map of under- and overexpression of genes in human cellsNature Methods - This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting...
Anne Carpenter@drannecarpenter.bsky.social

Now on biorxiv! The JUMP-Cell Painting Consortium’s paper: “Morphological map of under- and over-expression of genes in human cells” This is the genetic perturbation portion of the JUMP’s dataset; our chemical perturbation paper will come in a few months www.biorxiv.org/content/10.1...

biorxiv.orgMorphological map of under- and over-expression of genes in human cellsCell Painting images offer valuable insights into the state of a cell and enable many biological applications, but publicly available arrayed datasets only include hundreds of genes perturbed. The JUM...
Jess Ewald
@ewaldlab.org

Check out this opportunity to join my lab as a postdoc! www.ebi.ac.uk/research/pos... Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.

ebi.ac.ukEMBL-EBI-Sanger postdoctoral fellowships (ESPOD)The ESPOD fellowship builds on the collaborative relationship between EMBL-EBI and the Wellcome Sanger Institute, offering projects that combine experimental (wet-lab) and computational (dry-lab) appr...
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Jess Ewald
@ewaldlab.org

The visa is easy to obtain, for you and for any immediate family members. It allows a spouse to work in the UK. Please reach out with any questions!

Jess Ewald
@ewaldlab.org

Check out this opportunity to join my lab as a postdoc! www.ebi.ac.uk/research/pos... Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.

ebi.ac.ukEMBL-EBI-Sanger postdoctoral fellowships (ESPOD)The ESPOD fellowship builds on the collaborative relationship between EMBL-EBI and the Wellcome Sanger Institute, offering projects that combine experimental (wet-lab) and computational (dry-lab) appr...
Jess Ewald
@ewaldlab.org

Two days left before the application closes!

Jess Ewald@ewaldlab.org

🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium. More details & application here: lnkd.in/eHD7DMdX

Jess Ewald reposted

Beth Cimini 🔬💻📊
@bethcimini.bsky.social

We're once again hiring a summer (+?) #bioimage #bioimageanalysis #software intern! Due to requirements of the funding program, you must be a current student, as well as work onsite in MA (+ have US work permission). Details at the link below. Spend your summer making great tools with fun people!

forum.image.scSoftware engineering intern - summer/fall 2025 - Cambridge, MA USAIf you are a current student (undergraduate/masters/PhD) with permission to work in the US and ability to work in-person in Cambridge, MA, US, consider a summer internship in the Broad Institute Imagi...
Jess Ewald
@ewaldlab.org

🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium. More details & application here: lnkd.in/eHD7DMdX

Jess Ewald
@ewaldlab.org

Two EMBL-specific quirks: - EMBL salaries are "after tax", so the stated salary is roughly equivalent to $70k USD - Employees qualify for a quick & inexpensive visa exemption that allows them and their spouse/children to work in the UK (my visa was processed in 2 days and cost me $50USD)

Jess Ewald
@ewaldlab.org

5/ These findings demonstrate the potential of image-based profiling as a sensitive, animal-free, early-stage screening tool for compound toxicity.

Jess Ewald
@ewaldlab.org

3/ We then use supervised machine learning to predict diverse in vitro assay readouts relevant to mode-of-action and cell state using image-based profiles. We also investigate optimal strategies for extracting information from images to make mode-of-action predictions.

Jess Ewald
@ewaldlab.org

4/ We found that the morphological profiles detect compound bioactivity at lower concentrations than standard cytotoxicity assays. In supervised analyses, they predict cytotoxicity and targeted cell-based assay readouts, but not cell-free assay readouts.

Jess Ewald
@ewaldlab.org

2/ High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed. In our new preprint, we use Cell Painting and cytotoxicity assays to profile >1000 compounds in primary human hepatocytes, including pharmaceuticals, pesticides, and industrial chemicals.

Jess Ewald reposted

Beth Cimini 🔬💻📊
@bethcimini.bsky.social

New Year, new job? Delighted to announce two early-career-level (post-BA/BS or MA) positions in my lab, and an open call for computational postdocs at the Broad! First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)

docs.google.comImage analysis associate job descriptionImage Analysis Associate Broad Institute of MIT and Harvard, Cambridge, MA Impact the discovery of new disease therapies in the Cimini laboratory at the Imaging Platform Join our vibrant, world-clas...
Jess Ewald
@ewaldlab.org

🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉 We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods. I am beginning the search for two postdocs now - stay tuned for more details! ewaldlab.org

ewaldlab.orgEwald Lab@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
Jess Ewald
@ewaldlab.org

A new paper from the Carpenter-Singh Lab - such a cool project and I'm really excited about the possibilities that these data will unlock for future projects!

Anne Carpenter@drannecarpenter.bsky.social

Now on biorxiv! The JUMP-Cell Painting Consortium’s paper: “Morphological map of under- and over-expression of genes in human cells” This is the genetic perturbation portion of the JUMP’s dataset; our chemical perturbation paper will come in a few months www.biorxiv.org/content/10.1...

biorxiv.orgMorphological map of under- and over-expression of genes in human cellsCell Painting images offer valuable insights into the state of a cell and enable many biological applications, but publicly available arrayed datasets only include hundreds of genes perturbed. The JUM...

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