Erica Saint Clair, PhD

Erica Saint Clair, PhD

@esaintclair.bsky.social

Senior Scientific Analyst - Stansberry Research PhD Molecular Biophysics from Boston University

176 followers95 following191 posts

Erica Saint Clair, PhD
@esaintclair.bsky.social

Is anyone able to grab this for me? #icanhazpdf journals.physiology.org/doi/abs/10.1...

journals.physiology.orgHindlimb immobilization induces insulin resistance and elevates mitochondrial ROS production in the hippocampus of female rats | Journal of Applied PhysiologyAlzheimer’s disease (AD) is the fifth leading cause of death in older adults, and treatment options are severely lacking. Recent findings demonstrate a strong relationship between skeletal muscle and ...
Erica Saint Clair, PhD
@esaintclair.bsky.social

The participants were all Latino - which feels like a first in a study. I need to dig up the underlying paper to figure out how much of a change was really detected 🧪 #sleepapnea #neurology

scitechdaily.comIs Sleep Apnea Silently Reshaping Your Brain?Sleep breathing problems, like sleep apnea, may lead to changes in the hippocampus and white matter, impacting brain health and increasing dementia risk. A study on Latino adults revealed that those w...
Erica Saint Clair, PhD
@esaintclair.bsky.social

Guys! #ASH24 had a #puppy pen!! Look at this little guy! Apparently 4 or 5 puppies have been adopted so far, which is nuts. I can't imagine going to a conference and coming home with a puppy (despite deep desire and begging from my littles)

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Erica Saint Clair, PhD
@esaintclair.bsky.social

And 4/4. I am def not your person for questions - but anyone is always welcome to reach out to authors or presenters. I do that a lot for areas I research and always find people are more than happy to chat about their work. But of course, be kind to them :)

Erica Saint Clair, PhD
@esaintclair.bsky.social

Dr. Shan Liu just called out the Western diet as the "Fast Food" diet and she ain't wrong 😂 And look, the Western diet upped tumor volume... I have a good friend who came back from stage 4 lung cancer after a *massive* diet change, so I find this talk on #keto boosting #Car-T interesting #ASH24 🧪

Erica Saint Clair, PhD
@esaintclair.bsky.social

Dr. Shan Liu just called out the Western diet as the "Fast Food" diet and she ain't wrong 😂 And look, the Western diet upped tumor volume... I have a good friend who came back from stage 4 lung cancer after a *massive* diet change, so I find this talk on #keto boosting #Car-T interesting #ASH24 🧪

Erica Saint Clair, PhD
@esaintclair.bsky.social

What am I missing? The #cemsidomide MonoDACTM degrader results showed a patient case study. It looks like it worked great during the first month, but after a few months disease came back with a bang...and close to 9 in 10 pts discont. (I recognize its a heavily pretreated pop. & oral) #ASH24 🧪

Erica Saint Clair, PhD
@esaintclair.bsky.social

Big congrats to Dr Rachel Rau looking at #blinatumomab in kids. Adding it into standard #chemo significantly cut relapses and increased disease free survival. She mentioned the data monitoring board suggested a stop to randomization for efficacy. #ASH24 #ASH2024 🧪

Erica Saint Clair, PhD reposted

Scott McGrath
@smcgrath.phd

🧪 Researchers created Cervix-on-a-Chip, a microfluidic model mimicking the human cervix, revealing tissue responses to infections. This innovation may lead to new treatments for female reproductive diseases 🩺🖥️🧬

genengnews.comCervix on a Chip Latest Advance for Women’s HealthScientists developed a Cervix Chip to replicate tissue and microbiome interactions and offering a powerful new tool for studying women's health issues.
Erica Saint Clair, PhD
@esaintclair.bsky.social

🧪 Im not doing anything other than sitting on a couch late at night for this to ever be truly useful for me. But yet...I want a pair... Also - who is out running in the dead of night? Like maybe 0.0001% of the population?

scitechdaily.comRevolutionary Night Vision: Ultra-Thin Filters Transform Everyday EyewearResearchers have developed a groundbreaking thin infrared filter for night vision that can be integrated into everyday eyewear, allowing simultaneous viewing of the infrared and visible light spectra....
Erica Saint Clair, PhD
@esaintclair.bsky.social

🧪I could not list off any other cancer drug that maintains a 100% complete response rate at the 2 year mark. Is this a total unicorn? What's the catch?!? Anyone know of other drugs that got 100% CRR?

clinicaltrialsarena.comGSK’s Jemperli shows potential in Phase II trial for locally advanced rectal cancerGSK has reported updated results from a Phase II study of Jemperli for locally advanced mismatch repair deficient (dMMR) rectal cancer.
Erica Saint Clair, PhD
@esaintclair.bsky.social

🧪A sodium bicarbonate transporter (think baking soda transporter) helps seal the blood brain barrier after stroke. A bit over a year ago we also discovered the same transporter prevents pancreatic cancer from resisting immunotherapies. Oh, and lack of it creates cystic fibrosis like breathing

cell.comAstrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulationYe et al. highlight astrocytic Slc4a4’s role in astrocyte and BBB function under both normal and stroke conditions. Their study further emphasizes the significance of the Slc4a4-CCL2-CCR2 axis in BBB ...
Erica Saint Clair, PhD
@esaintclair.bsky.social

Um yes. Ten thousand times yes! If AI can't clean house physically, maybe it can clean house emotionally. If it's trained right, I am all for this (that is, of course, a HUGE caveat)🧪

uwaterloo.caAI saving humans from the emotional toll of monitoring hate speech |A team of researchers at the University of Waterloo have developed a new machine-learning method that detects hate speech on social media platforms with 88 per cent accuracy, saving employees from
Erica Saint Clair, PhD
@esaintclair.bsky.social

Wait, so there's still a faulty valve 👀👀...and they're confident 27 of 28 thrusters are working 👀👀. Seems like launching without fixing issues is a bad plan. If I were headed into *space* I would want everything to be up to snuff. 🧪

dailymail.co.ukBoeing to launch rocket - despite warning from NASA contractorThe first manned mission of Boeing's Starliner spacecraft is set to launch Saturday, after an earlier attempt was scuttled over a leaking valve on one of its oxygen tanks
Erica Saint Clair, PhD
@esaintclair.bsky.social

🧪 Fentanyl is a one two punch-boosts positive feelings while on drug, and uses another circuit to make withdrawal particularly nasty - both rely on mu receptors. Makes me wonder about the dev of other opioid pain killers that target other paths, like kappa. Will the FDA still shy away?

nature.comFentanyl addiction: the brain pathways behind the opioid crisisHow two neural pathways contribute to the deadly opioid’s addictive nature, and why babies are suing the South Korean government. Hear the biggest stories from the world of science | 22 May 2024
Erica Saint Clair, PhD
@esaintclair.bsky.social

This is super cool. I'd also love to program if to be able to zone in on a specific voice. Like say...mine, when trying to get the hubs attention while listening to audiobooks and what not around the house... 🧪

washington.eduAI headphones let wearer listen to a single person in a crowd, by looking at them just onceA University of Washington team has developed an artificial intelligence system that lets someone wearing headphones look at a person speaking for three to five seconds to “enroll” them. The...
Erica Saint Clair, PhD
@esaintclair.bsky.social

Everywhere we look in the body, we're finding microplastics. Microplastics: -in the prostate might be lowering sperm count -in arteries quadruples heart attack/stroke risk -can cross the BBB and change cognition (in mice) We're all just along for the ride at this point but... 👀👀👀 🧪

bmcurol.biomedcentral.comThe first reported values of microplastics in prostate - BMC UrologyBackground Microplastics are ubiquitous, widespread environmental pollutants with unavoidable human exposure. Herein, it was aimed to investigate the presence of microplastics in prostate tissue. Meth...