iScience

iScience

@cp-iscience.bsky.social

iScience is the interdisciplinary journal from Cell Press publishing across life, physical, earth, health, and social sciences.

741 followers44 following90 posts

iScience
@cp-iscience.bsky.social

Online now: NDUFAF2 promotes abdominal aortic aneurysm formation through mitochondrial dysfunction-induced apoptosis

dlvr.itNDUFAF2 promotes abdominal aortic aneurysm formation through mitochondrial dysfunction-induced apoptosisAbdominal aortic aneurysm (AAA) is a life-threatening vascular disease closely associated with mitochondrial dysfunction and apoptosis. Here, we found that NDUFAF2 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 2) was significantly upregulated in cultured cells and murine AAA tissues. Knockdown of NDUFAF2 in vitro attenuated Ang II-induced mitochondrial fragmentation, reactive oxygen species (ROS) production, and apoptosis in vascular smooth muscle cells (VSMCs), while improving mitochondrial membrane potential and oxygen consumption rate.
iScience
@cp-iscience.bsky.social

Online now: Chronotherapy for retinopathy: Unraveling the mystery of Rev-erbα in the circadian rhythm

dlvr.itChronotherapy for retinopathy: Unraveling the mystery of Rev-erbα in the circadian rhythmDisruption of the retinal circadian rhythm is a common manifestation of various retinal diseases, characterized by abnormal expression of clock genes and impaired light signaling in intrinsically photosensitive retinal ganglion cells (ipRGCs). This review aims to elucidate the mechanisms of circadian disruption in retinal pathologies, explore the interrelationship between clock genes and ipRGCs, and delineate the therapeutic potential and directions of chronotherapy for retinopathies. Through a systematic retrieval and analysis of literature on retinal diseases and circadian rhythms from databases including PubMed and Web of Science, this review reveals that Rev-erbα and melanopsin form an antagonistic system within the retina, regulating the intraocular dopamine-melatonin rhythm and maintaining retinal homeostasis.
iScience
@cp-iscience.bsky.social

Online now: Sleep deprivation impairs ventral hippocampus-medial prefrontal connectivity and task learning in rats

dlvr.itSleep deprivation impairs ventral hippocampus-medial prefrontal connectivity and task learning in ratsSleep is essential for memory consolidation, and sleep loss has long been associated with cognitive impairment. However, the circuit-level mechanisms through which sleep deprivation disrupts hippocampal–prefrontal communication during learning remain poorly understood. Here, we combined a T-maze learning task with simultaneous local field potential (LFP) recordings in the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) of rats. Using dynamic causal modeling (DCM), we quantified directional connectivity during task acquisition under normal and sleep-deprived conditions.
iScience
@cp-iscience.bsky.social

Online now: SCML1 overexpression promotes DNA damage and improves the therapeutic efficacy of cisplatin for ovarian cancer

dlvr.itSCML1 overexpression promotes DNA damage and improves the therapeutic efficacy of cisplatin for ovarian cancerOvarian cancer (OVCA) is one of the most common gynecological tumor and is the eighth most common cause of cancer death in women Sex comb on midleg-like 1 (SCML1) plays an important role in the regulation of embryonic development, but its role in ovarian cancer has not been detected. SCML1 was identified to be associated with cisplatin resistance in OVCA. The expression of SCML1 in OVCA tissues was verified by testing clinical samples. The effect of SCML1 on the proliferation and drug resistance of OVCA cells was investigated in vivo and in vitro.
iScience
@cp-iscience.bsky.social

Online now: Electromagnetic Modeling of Bundle Branch Block and Application in Magnetocardiographic Diagnosis

dlvr.itElectromagnetic Modeling of Bundle Branch Block and Application in Magnetocardiographic DiagnosisBundle branch block (BBB) causes delayed and asynchronous ventricular activation. This study proposes an integrated framework that links biophysically interpretable magnetocardiography (MCG) features to ventricular electrophysiology using both simulations and clinical recordings. We performed whole-heart electrophysiological simulations to examine how conduction block alters ventricular depolarization and shapes QRS morphology in MCG. We then collected 32-channel OPM-MCG data from 416 subjects (203 BBB, 213 controls) and extracted two time-domain features—QRS width and QRS complexity—followed by logistic-regression classification.
iScience
@cp-iscience.bsky.social

Online now: Design strategies and anti-tumor applications of nanorobots

dlvr.itDesign strategies and anti-tumor applications of nanorobotsMalignant tumors remain a major global health challenge due to their heterogeneity, poor therapeutic specificity, and frequent development of multidrug resistance. Conventional treatment strategies are often hindered by limited tumor penetration, systemic toxicity, and the immunosuppressive tumor microenvironment. In recent years, nanorobots—engineered nanoscale devices with autonomous or guided navigation capabilities—have emerged as a transformative platform in precision oncology. These intelligent systems integrate active targeting, stimuli-responsive drug release, and multifunctional therapeutic modules, enabling dynamic interactions with the tumor milieu.
iScience
@cp-iscience.bsky.social

Online now: CNTs@ZIF-67 Conductive Composite Nanoparticles Enhance the Electromagnetic Shielding Performance of Tough Organic Hydrogels

dlvr.itCNTs@ZIF-67 Conductive Composite Nanoparticles Enhance the Electromagnetic Shielding Performance of Tough Organic HydrogelsWith the widespread use of electronic devices, electromagnetic radiation pollution has become increasingly severe, posing potential threats to human health and the ecological environment. This study successfully prepared a tough, adhesive, green, and multifunctional semi-interpenetrating network organic hydrogel using a three-step method, and enhanced its electromagnetic shielding performance by incorporating CNTs@ZIF-67 composite nanoparticles. An environmentally friendly semi-interpenetrating network organic hydrogel was constructed using polyvinyl alcohol (PVA) and bio-based gelatin (Gel).
iScience
@cp-iscience.bsky.social

Online now: Study on the Adsorption of Rose Anthocyanins by Rose Residue Activated Carbon

dlvr.itStudy on the Adsorption of Rose Anthocyanins by Rose Residue Activated CarbonThe extraction technology for rose anthocyanins is becoming increasingly sophisticated, and the activated carbon prepared from biological materials has abundant pores and strong chemical stability, low production cost, and can be recycled. Therefore, activated carbon was prepared from rose pomace to adsorb rose anthocyanins. The results show that the best static adsorption process parameters are RP-AC at 1.1 g, the crude extract concentration of anthocyanin at 30 mg/L, adsorption time of 20 h, pH=2; the best dynamic adsorption parameters are 1 mL/min and the sample concentration of 50 mg/L.
iScience
@cp-iscience.bsky.social

Online now: Synthesis of domestic and international studies on the layout of synchrotron light source installations

dlvr.itSynthesis of domestic and international studies on the layout of synchrotron light source installationsThis study analyzes global trends in synchrotron light source (SLS) facility development, showcasing their essential function in materials, biology, and chemistry research. By mapping current and planned installations, we identify key growth areas and their implications for scientific and industrial innovation, and many other scientific and technological fields. The paper evaluates core design principles, layout optimization approaches, and technical specifications of prominent SLS facilities, contrasting domestic and foreign advancements.
iScience
@cp-iscience.bsky.social

Today’s highlight is by K. Wang and colleagues. Lower vitamin D levels are linked to inflammation and reduced uterine blood flow in pregnancy, and to higher risk of pregnancy loss 🧬 Vitamin D status may be a useful marker for reproductive risk stratification. www.cell.com/iscience/ful...

cell.comVitamin D status tracks inflammation perfusion and pregnancy in polycystic ovary syndromeImmunology; Clinical medicine; Biochemistry; Genetics; Molecular biology; Neuroscience; Cell biology; Computational bioinformatics
iScience
@cp-iscience.bsky.social

iScience Collection: Food🍲 Chemistry 🧪—sustainable materials, catalytic advances, and next‑gen, data‑driven analytics for safer, smarter, sustainable food systems 🍃. Explore: www.cell.com/iscience/col... #FoodChemistry #SustainableFood #FoodScience #SustainableMaterials #InterdisciplinaryResearch

iScience
@cp-iscience.bsky.social

iScience collection : The Application of Artificial Intelligence 🖥️ 🤖 in Cancer Diagnosis 🔬 A curated collection showing the transformative potential of AI to improve diagnostic precision and patient outcomes in oncology. 👉: www.cell.com/iscience/col... #CancerResearch #MachineLearning #AI

cell.comThe Application of Artificial Intelligence in Cancer Diagnosis: iScienceiScience Editors have curated this collection of articles showcasing the latest developments in cancer diagnosis using AI and machine-learning.
iScience
@cp-iscience.bsky.social

Our iScience editor Dr. Jessica Tom will be attending the upcoming European Materials Research Society Spring meeting in Strasburg from May 25-29. Get in touch for more info about publishing your research in iScience – email: jtom@cell.com. #EMRS #EMRS2026 #EMRSSpringMeeting #EMRSSpring2026

iScience
@cp-iscience.bsky.social

We’re excited to share that our iScience deputy editor Rituparna Chakrabarti will be attending the upcoming Organoid NL Symposium in Amsterdam this week. Get in touch to discuss publishing your research in iScience – email: r.chakrabarti@cell.com. #OrganoidNL #Organoids

iScience
@cp-iscience.bsky.social

Todays highlight is by Wenzhe Sun and colleagues. An AI-powered approach that improves H2S/SO2 forecasting in sulfur recovery units, helping refineries cut emissions😶‍🌫️ and run more efficiently. #IndustrialAI #SulfurRecovery #RefineryOptimization www.cell.com/iscience/ful...

cell.comHybrid Multiscale Forecasting of SRU Sulfur Gas Concentrations Using VMD CEEMDAN and Optimized PatchTSTThe sulfur recovery process in SRUs is highly nonlinear and non-stationary, making accurate forecasting of H2S and SO2 concentrations challenging yet crucial for efficient, low-carbon operation. Many ...
iScience
@cp-iscience.bsky.social

Call for Papers!📢 iScience Special Issue: Water Management in Times of Disasters and Conflicts - we welcome research on governance, water diplomacy and approaches to management of water resources during crises💧 www.cell.com/iscience/spe... #WaterDiplomacy #WaterGovernance #WaterResources

iScience
@cp-iscience.bsky.social

🤔 Ever wondered how tiny miRNAs shape #βCell #insulin release in #Type2Diabetes? New iScience research maps miRNA-mRNA networks in human #islets & spots key players like miR-101-3p linked to secretion pathways 🚀 🧾 www.cell.com/action/showP... #miRNA #DiabetesGenomics #Endocrinology #CellBiology

iScience
@cp-iscience.bsky.social

What makes a scent unlock a memory? 👃🧠 This #iScience study shows how #OlfactoryMemory emerges from emotion, familiarity, and #SemanticRichness, teasing apart recognition vs association 🌸✨ 🧾Read more: doi.org/10.1016/j.is... #Smell #EpisodicMemory #CognitiveNeuroscience #SensoryScience

iScience
@cp-iscience.bsky.social

Check out this new study at @cp-iscience.bsky.social

Adrien Hamandjian@ahmycologist.bsky.social

Our paper is out in @cp-iscience.bsky.social ! We studied how secretory vesicles accumulate at the tips of growing fungal filaments, uncovering overlooked spatial and temporal diversity. A step forward in understanding fungal growth dynamics. More at www.sciencedirect.com/science/arti...