Corcoran Lab

Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression: Molecular Cell www.cell.com/molecular-ce...

Very excited to share our newest work.

So happy to have this story out! What started as a project about the protein products of a polycistronic mRNA ended up becoming a story about how RNA-mediated assembly of nuclear speckles promotes viral gene expression. What a ride, some very good days on the microscope!! 🔬 @corcoranlab.bsky.social

Our study of coronavirus structural proteins that interfere with host responses to infection, led by Drs. Taylor Caddell and Eric Pringle, with support from colleagues @rorymulloy.bksy.social and @corcoranlab.bsky.social, is now published in @PLOSPathogens journals.plos.org/plospathogen... (1/8)

Do you like microscopy? Do you think viruses are cool? Do you want to advance our understanding of one of the world's most important pathogens? Come and do your PhD with myself and the fantastic @peacockflu.bsky.social, at @pirbrightinst.bsky.social and @cvrinfo.bsky.social 🤓🦠🐓

#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr

Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social Details in the thread below - please share! Deadline 8th May 2026, fully funded for UK Home students (1/4)

So proud to have worked alongside @rorymulloy.bsky.social and @corcoranlab.bsky.social on this amazing project, now out in @plosbiology.org! journals.plos.org/plosbiology/...

#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr

New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods

This is an incredibly moving thread.

The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study #Oropouche virus, (probably) the most important virus that you’ve never heard of: doi.org/10.1101/2025... Bluetorial follows 🟦🧵

Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran www.biorxiv.org/content/10.1...

Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...