Claus Wilke

Claus Wilke

@clauswilke.com

Computational biologist, data scientist, occasional blogger | https://blog.genesmindsmachines.com/ | https://clauswilke.com/ | Opinions are my own and do not represent UT Austin.

6.3K followers475 following1.1K posts

Obviously the solution is to never take a break. The AI doesn't take a break either.

Simon P. Couch@simonpcouch.com

New on the @posit.co open source blog: if you step away from your coding agent long enough to make a coffee, your next message could cost ~16x as much☕ @sara-altman.bsky.social and I wrote about token caching and AI costs: opensource.posit.co/blog/2026-10...

A graduate student working on methane being on fire doesn't sound like a good thing to me. I hope he's fine.

Holly Bik@hollybik.bsky.social

My grad student Min Khant Han @baldbiologist.bsky.social is on fire lately with his #scicomm work from a methane seep expedition with the Joye lab! (And we are all impressed that his Instagram reel of an amphipod doing 6-7 arms got 500k views 😂😂😂)

Claus Wilke reposted

1/ Over the weekend, there was a reported case of plague in Russia. I’m seeing a lot of rumors about the event being spread without facts to back it up, so I wanted to jump on here to break down what we do and don’t know about this situation and whether or not you should be concerned.

There's nothing wrong with reaching out early, and if the response you get is "get back to me in a couple of months" then you do that. 1/2

This post is unavailable.

From my perspective, reaching out early is good b/c sometimes I have a pending grant and when it finally gets awarded I can just go back to the student who expressed interest and maybe they're just about ready to graduate. This has happened to me more than once. 2/2

Often grants arrive some months after their official start date, and if you then have to start searching for candidates you may be halfway through the first budget period before you've even staffed your positions. I try to avoid this if I can. 3/2

Implementing oral exams at scale. The paper describes oral exams for hundreds of students, 5 min. each over zoom, administered by graduate TAs. My thoughts: It's doable but not easy. 5 min. is super short, yet it's tough for the TAs do to ~100 exams. www.tandfonline.com/doi/full/10....

tandfonline.comImplementing Oral Exams at Scale: Experiences from Graduate Student InstructorsThis paper describes the implementation of oral exams, a more authentic and potentially more informative form of assessment than written exams, at a large scale (over 600 students), in the context ...

Overall, it's not clear to me that this type of oral exam adds much. I think oral exams need to be longer than 5 min., but then the issue of scale becomes even more pressing. And/or, you need to do more than one oral exam per semester.

I'm wondering whether it's possible to do some sort of in-class graded oral activity, such as having a few students each class present on something for 5 min. This is half-baked, but just something I'm pondering.

Claus Wilke reposted

Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc

nyti.msDid Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.

I read some research once that said this was typical. It matches my own experience. I can easily switch between English and Italian but German lives in a different part of my brain and it's hard both to switch into and out of.

This post is unavailable.

Claus Wilke reposted

“Looking into what the evidence says once or twice every decade feels like a good cadence.” We’re impatient beings, but this is so grand. Not just with Covid, but political autopsies, giant crimes, divorces, etc

Claus Wilke@clauswilke.com

I wrote up my thoughts about the COVID origin. I don't plan to weigh in on the topic beyond this one post for the next five years or so. Looking into what the evidence says once or twice every decade feels like a good cadence. blog.genesmindsmachines.com/p/it-still-w...

Claus Wilke reposted

When you can, devote a little of your time to this. It will be worth it. 🧪

Claus Wilke@clauswilke.com

I wrote up my thoughts about the COVID origin. I don't plan to weigh in on the topic beyond this one post for the next five years or so. Looking into what the evidence says once or twice every decade feels like a good cadence. blog.genesmindsmachines.com/p/it-still-w...

Claus Wilke reposted

Controversial, not so controversial, take - the dangers posed by AI are real, current, and well-documented. Those do not include human extinction within a decade, nor do they include AI-manufactured-printed-out-in-the-lab bioweapons, yet, those are the ones we chose to focus on. Good lord.

The reason Claude did well at binder design is because the prompt hardcoded that it should use ESMFold2 for scoring, and apparently ESMFold2 is really good. It's also only a few months old so not widely used yet. AI in biology keeps disappointing. blog.genesmindsmachines.com/p/anthropic-...

blog.genesmindsmachines.comAnthropic has not solved the peptide-binder design problem, but maybe bi[o]hub hasThe protein design field is getting pushed forward by human experts in protein design, who would have thought

Claus Wilke reposted

You may have seen that Claude can now design peptide binders. I'm not quite sure what to make of this, but I'm quite certain Claude has not unlocked anything new that wasn't already available in all the standalone tools that are floating around. blog.genesmindsmachines.com/p/has-anthro...

blog.genesmindsmachines.comHas Anthropic solved the peptide-binder design problem?A small step towards curing all of human disease within the next ten years

Claus Wilke reposted

Agree

Claus Wilke@clauswilke.com

You may have seen that Claude can now design peptide binders. I'm not quite sure what to make of this, but I'm quite certain Claude has not unlocked anything new that wasn't already available in all the standalone tools that are floating around. blog.genesmindsmachines.com/p/has-anthro...

Claus Wilke reposted

"What really bothers me about these stories about how AI will design killer viruses is that they are pure fear mongering, and more importantly they divert attention from the things that matter". Indeed 🎯.

Claus Wilke@clauswilke.com

I'm really frustrated by the constant fear-mongering about AI-designed superviruses. Can we focus on the things that should actually worry us, such as measles? blog.genesmindsmachines.com/p/im-sorry-y...

Claus Wilke reposted

a good take. the dominant philosophy in AI circles leads to some very strange places, which should really earn more scrutiny of the philosophy itself

Claus Wilke@clauswilke.com

I'm really frustrated by the constant fear-mongering about AI-designed superviruses. Can we focus on the things that should actually worry us, such as measles? blog.genesmindsmachines.com/p/im-sorry-y...

There are many solutions to the challenge of F chords: - Get a smaller guitar (have you tried electric?) - Use thinner strings - Switch to piano - Tune your guitar half a note higher

This post is unavailable.

If I read this correctly, program officers would not see any ranking differences among the top 25% of applications. Which immediately begs the question of how applications within this group would be chosen for funding. Lottery? Personal preference of the PO? Choice by LLM?

Unpopular opinion: If I can pay for guaranteed overhead bin space I'll happily do so. I'm so tired of "having my bag checked for free to the final destination" where then I have to wait for 30 min or longer to retrieve my small carryon. 1/2

William J. McGee@wjm-air.bsky.social

Airlines charging for overhead bin space is already happening in the Pacific Rim. What are the betting odds on this spreading to the United States? www.frommers.com/tips/airfare...

In particular after long international flights that final wait is super grating. And often it's the difference between being ahead of the line in the immigration queue or getting stuck in the middle. 2/2

Claus Wilke reposted

Russian "human safari" in Kherson continues. Police have released footage showing Russians using a drone to hunt a civilian in the city. The victim is a 52-year-old market vendor from the Mykolaiv region, who suffered a blast injury, shrapnel wounds, and a concussion.