Scott Coyle

Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...

Check out an epic new study by star student Matt Howard 🤩!!! We've been working on this for many years and we generate a ridiculous amount of data to address a classic gpcr question using the opioid receptor as a model - how do ligands binding to the same site activate receptors to varying degrees!

🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

Please enjoy this new offering from the lab: we discover that #excavates - ancient flagellate lineages with a voracious appetite for bacteria - change their behaviour depending on the availability of said prey! Preprint here: www.biorxiv.org/content/10.6... #protistsonsky

A colleague just thoughtfully dropped this off for me. I had never heard of it before, but it turns out to be a fantastic little resource for protist identification. Nice drawings with good descriptions of behavior and sampling tips. #protistsonsky

i'm happy to share that our lab has joined @foxchasecancer.bsky.social! v proud of what our team achieved in Madison & now we look forward to this next chapter in the vibrant Philly scientific ecosystem - actively recruiting at all levels across the biological sciences and engineering!

Going strong today with the sampling team ! Such a Bliss to be outdoors honnestly.

Excited to share my first preprint from my PhD work in the Bement lab 🥳 💝 We discovered a previously unrecognized function of the RhoGAP RGA-3/4: RGA-3/4 directly and cooperatively binds to F-actin and reorganizes it by crosslinking actin filaments www.biorxiv.org/content/10.6...

🏆 Biochemist Martin Jinek is the winner of the Swiss Science Prize #MarcelBenoist 2026, considered the Swiss #Nobel Prize. He contributed to the development of molecular scissors, namely CRISPR-Cas9 technology. Read more ➡️ sohub.io/3hs4

We wrote a tutorial guide on voltage imaging, now out in Neuron: authors.elsevier.com/a/1nlgh3BtfH... Indicators, microscopes, and software have all advanced to the point that it's not so hard -- you can now directly watch the electrical activity of neurons in live animals or in culture.

Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!

📢 Institut Jacques Monod Seminar 📅 September 18th 📍Institut Jacques Monod Tomorrow, Prof. Omaya Dudin ( @dudinlab.bsky.social ) will present an Institut Jacques Monod seminar on the theme "Exploring multicellular developmental programs at the root of animals and beyond ➡️ buff.ly/3RGKbbU

Proud to see this paper lead by my amazing student Regan finally out in the world! Using chemical biology approaches, we reveal a transcriptionally silent process by which macrophages acquire new functional proteins from the surface of interacting cells.

Excited to share our new collaborative paper in Development @biologists.bsky.social 😀 🎉 Led by Cyndi Bradham's lab @bostonu.bsky.social & Abigail Descoteaux, we show that Alizarin Red can perturb sea urchin skeletal development via catalase inhibition @univmiami.bsky.social doi.org/10.1242/dev....

Princeton postdoctoral fellowship opportunity to work in my lab & others! This opportunity is part of a new NSF-funded center here, and is particularly focused on candidates who are interested in biomolecular condensates and programmable soft materials. Deadline Nov 1. apply.interfolio.com/193107

Absolutely ecstatic to share that WE GOT THE COVER!!! 🥹🎉 Seeing this on NCB's cover feels surreal. So much time, science, and teamwork went into this project, and I couldn’t be more excited to see it celebrated like this. A very, very happy day for this really really old and grown embryo 🐭🧫💥

Thrilled to share that I’ll be starting as an Assistant Professor in Mechanical Engineering at UC Berkeley in January 2027! @ucberkeleyofficial.bsky.social @berkeleyengineer.bsky.social I’ll be launching the Deep Lab for Microbial Biomechanics. 🧵 1/8

Congratulations to Wallace Marshall of UCSF, recipient of the 2026 Keith R. Porter Lecture, honoring innovative leaders advancing our understanding of cell biology. https://www.ascb.org/society-news/ascb-announces-2026-honorific-award-winners/

My MCDB Dept is hiring, again! Assistant Professor Faculty Search. Please Repost! Applications Due Oct 1st We welcome applications from all areas of cellular/molecular biology in prokaryotes, plants, and animals. More information can be found HERE: jobs.sciencecareers.org/job/679540/a...

What's that? You wish we had more data on those bizarre dinoflagellates WITH EYES? Have no fear! With @protistwtmostest.bsky.social, Gordon Lax, and @pjkeelinglab.bsky.social, who also have eyes.

🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical? Thrilled to share our new paper in @NatureCellBio : Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇 www.nature.com/articles/s41... 1/11

And finally—a bit of personal news: 🔬 I’m on the faculty job market this year! I’m looking for tenure-track opportunities where I can build a lab at the intersection of developmental biology, mechanobiology, reproductive biology & aging.

Now published as Editor's Pick in mBio! Congrats once again to @claire-dudley.bsky.social and all co-authors! journals.asm.org/doi/10.1128/...

Checkout 𝘚𝘢𝘱𝘱𝘪𝘯𝘪𝘢 𝘭𝘶𝘬𝘰𝘭𝘪, a new species of amoeba isolated from cow poop that aggregates on the tips of dung fibers doi.org/10.64898/202... #ProtistsOnSky

Endocytic clathrin coats are surprisingly dynamic: triskelia turn over in seconds. How is the turnover regulated and what is it for? Read Anne-Laure Boinet's preprint with @rouxlab.bsky.social www.biorxiv.org/content/10.6...

We're #hiring! The Department of Biochemistry is looking for a professor at any level to join our creative and dynamic community. Candidates in all #biochemistry areas will be considered. Apply by October 15 for full consideration: jobs.wisc.edu/jobs/assista...

Discovery of a Turing reaction-diffusion system in Archaea! www.biorxiv.org/content/10.6...

New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...

What can a microscopic organism in Lake Mendota teach us about cellular adaptation? The @cellraiser.bsky.social Lab is studying P. collini, a single-celled predator that reshapes its feeding structures to match changing conditions in its environment. Read the story: biochem.wisc.edu/2026/07/16/i...

Initial set of our new T1 T-DNA vectors now available on @addgene.bsky.social: pT1 (no selection marker): lnkd.in/dcnTN8Rj pT1-B (BASTA selection marker): lnkd.in/dgTZmuCx pT1-K (kan selection marker): lnkd.in/dqgv4QRc pT1-H (hygro selection marker): lnkd.in/dhrs5Tsg

Very excited to announce that my paper with @toettch.bsky.social from my time as a Fellow at Princeton's Center for the Physics of Biological Function @cpbf.bsky.social is finally out as a preprint! Here is the link if you want to check it out: www.biorxiv.org/content/10.6... A thread: (1/10)

A minimal lipid kinase/phosphatase system, two effector proteins from Legionella pneumophila, self-organizes together with its lipid substrates (PI/PI3P) into dynamic patterns on membranes. Check out our preprint: www.biorxiv.org/content/10.6...

New preprint! How does a cell "know" how big to make its nucleus? This has puzzled biologists since the 1800’s. We show the answer is physics: colloid osmotic pressure. 🧵1/5

A bit late but…Tenured! Immense gratitude for those who got us here. Firstly the students/postdocs (too many to list!) who took a chance on an unproven lab and were unafraid to pursue some strange new ideas. I couldn't have predicted our path, and I couldn’t be more excited for what's next.

Had a lot of fun writing this dispatch article for @currentbiology.bsky.social with PhD student Caitlin Doyle www.sciencedirect.com/science/arti..., highlighting cell morphogenesis and recent work on suctorian growth control principles. 1/3

We developed a new approach for mapping absolute membrane voltage, based on dynamic photocycle control in Voltron2. www.biorxiv.org/content/10.6... Here's my favorite example: human iPSC colonies break into electrical domains as they begin to differentiate.

The STRAIGHT-IN (Dual) kit is now available via @addgene.bsky.social! 🧬 A complete 24-plasmid toolkit for installing up to two orthogonal CLYBL landing pads, DASIT-based enrichment without FACS, and efficient large DNA integration in human cells. Link: www.addgene.org/kits/gallowa... 🧵

🔬 #JobAlert Interested in doing a PhD with us in #SyntheticBiology on the Reconstitution of Oscillatory Microtubule-Motor Systems? Check shorturl.at/wis5P (note the eligibility criteria) or/and get in touch with us shorturl.at/WmgOD. Deadline: 31 July 2026 #WeAreHiring #AcademicJobs #ScienceJobs

How did octopuses evolve novel traits? Rishav Mitra, Richard Han, Trey Scott, et al serendipitously discover a unique ribosome adaptation that increases the accuracy of protein synthesis and evolved alongside their elaborate nervous systems vs deep sea relatives. www.biorxiv.org/content/10.6...

Congrats to our talented postdoc @amirbitran.bsky.social for his first preprint in the lab, a collaboration with the Bustamante lab, studying time-resolved protein folding during translation elongation with HDX-MS! Check out the attached manuscript and tutorial for more:

Engineering Modular Cargo Loading Strategies for Carboxysome-Derived Protein Particles | ACS Synthetic Biology @cellforganized.bsky.social

Beautiful work (and beautiful figures!) from Sashital lab alum @yuktidhingra.bsky.social! Congrats, and looking forward to seeing more exciting RNAP work in the future!

Had a blast putting this video abstract together with colleagues for @zjmaggiexu.bsky.social story in @currentbiology.bsky.social on how the "vampire cell" P. collini builds the perfect feeding trap 👀. Be sure to check out the full paper: www.cell.com/current-biol... www.youtube.com/watch?v=Ikzm...

A High-Affinity Nanobody Recognizing mNeonGreen Enables Versatile Biochemical, Cellular, and in vivo Applications. by Steffen Frey and team: www.biorxiv.org/content/10.6...

Happy Canada Day to all my fellow Canadians out there! 🇨🇦🍁

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

Folks, mind the suctorian trap!

I had a ton of fun the other day talking with @nonresidentdesi.bsky.social and @scifri.bsky.social 's Flora Lichtman and Rasha Aridi about murderous microbes and the things that we are trying to learn from them. Happy for the opportunity to bring some new awareness to the world of protists!

Researchers like Ben Larson and Glen D’Souza are piecing together the world of killer microbes, including why they turn on each other and if their tiny weapons could be harnessed to fight disease. Listen to the podcast now: www.sciencefriday.com/segments/kil...