Chris Bahl

Chris Bahl

@cdbahl.com

protein geek, founder and CEO of AI Proteins @aiproteins.com https://linkedin.com/in/cdbahl

1.3K followers84 following64 posts

We signed a new research collaboration and license agreement! @aiproteins.com will design and optimize de novo #miniproteins to multiple targets, and Astellas Pharma will do development & commercialization. This division of labor will help get new medicines to patients with the urgency they deserve.

We always strive for our work to substantially benefit the greater scientific community, and it's such a thrill every time it happens. A massive thank you to @addgene.bsky.social for amplifying the impact of researchers everywhere! 🧵👇

View full thread

We always strive for our work to substantially benefit the greater scientific community, and it's such a thrill every time it happens. A massive thank you to @addgene.bsky.social for amplifying the impact of researchers everywhere! 🧵👇

This Blue Flame Award is for a plasmid encoding an improved SUMO protease enzyme, and it was the work of an amazing team: Kara Lau, Vladimir Baytshtok, Tessa Howard, Brooke Nickerson, JayLee Johnson, Lauren Carter, David Baker and Chris Lima www.jbc.org/article/S002...

jbc.orgDiscovery and engineering of enhanced SUMO protease enzymesSmall ubiquitin-like modifier (SUMO) is commonly used as a protein fusion domain to facilitate expression and purification of recombinant proteins, and a SUMO-specific protease is then used to remove ...

Chris Bahl reposted

Chris Bahl reposted

🧬 Figure Friday AI is making protein design faster, but can protein production keep up? Edson Noriega, Chris Bahl & colleagues developed a high-throughput workflow for rapid protein purification, demonstrated across 96 diverse proteins.

Chris Bahl reposted

🧬 Want to stay updated on protein science? Check out the @bpdmc.org monthly presentation series! Recent topics: • Computational antibody design • Energy-based models & structure • De novo small-molecule induced changes Learn more, watch past presentations, and join the community at bpdmc.org.

Chris Bahl reposted

Power up your protein purification with a new SUMO protease construct from @cdbahl.com and team! Find individual plasmids here: www.addgene.org/browse/artic... Or get the full benchmark set: www.addgene.org/kits/bahl-su...

addgene.orgAddgene: Facile, high-throughput protein purification enabled by high-efficiency protease elution.
Chris Bahl@cdbahl.com

The data, code, and detailed protocols are all available on github github.com/aiproteins/h... and all the plasmids are available on addgene www.addgene.org/233685/ www.addgene.org/233686/ www.addgene.org/kits/bahl-su...

Every protein designer knows that producing & testing designed proteins is a foundational capability for our field, & this is still pretty challenging for a lot of folks. This is why I'm delighted to share our work to make high-throughput protein production more accessible dx.doi.org/10.1002/pro....

dx.doi.orgFacile, high‐throughput protein purification enabled by high‐efficiency protease elutionWhile advances in artificial intelligence have made protein design widely accessible, protein production and characterization remain a bottleneck. Protease-cleavable affinity tags are commonly used t....
View full thread

We look forward to seeing all of the exciting results that people generate using this method, and please don’t hesitate to reach out to any of us if you have questions!

Every protein designer knows that producing & testing designed proteins is a foundational capability for our field, & this is still pretty challenging for a lot of folks. This is why I'm delighted to share our work to make high-throughput protein production more accessible dx.doi.org/10.1002/pro....

dx.doi.orgFacile, high‐throughput protein purification enabled by high‐efficiency protease elutionWhile advances in artificial intelligence have made protein design widely accessible, protein production and characterization remain a bottleneck. Protease-cleavable affinity tags are commonly used t....

Peer-reviewed science that is verifiable and can be built upon remains essential, and we strongly believe in the value of sharing technology openly and freely with the community

Science is a team sport, and this project had an amazing team: Edson Cárcamo, Ian Truebridge, Frank Teets, James Bowman, Nathalia Rodriguez, and Tessa Howard

Chris Bahl reposted

We can design "static" binders routinely now, but design of "dynamic" shape-changing proteins has remained quite hard. Jeffrey Chang and I asked: why can't we couple small-molecule binding to shape change? After all, natural proteins do it every day. In a new preprint, we show how it can be done. 🧵

Chris Bahl reposted

We're delighted to kick off our new seminar series, and the inaugural speaker is none other than Neil King from the Institute for Protein Design, University of Washington "ML-based design of nanoparticle vaccines" June 3rd, 2026 12:00 PM – 1:00 PM EDT

Chris Bahl reposted

I never imagined this would happen ~8+ years ago. Just, wow. I'm so grateful to everyone in this community and for all the support and help from the many people that made it possible.

We just passed an exciting milestone: our one thousandth member just joined @bpdmc.org! Thank you so much to everyone who has made this journey possible, and we're excited to welcome many more wonderful folks to our nerdy protein club! For more info, check out bpdmc.org

We've got two more positions open for RAs to join AI Proteins! One opening is for our Protein Characterization group led by Alyssa Anderson, and the other is for our Biochemistry group led by Edson Carcamo. These wet lab roles are a perfect for college students who are graduating this spring.

AI Proteins@aiproteins.com

Our team is growing! We’re hiring for two new roles on our Biochemistry and Protein Characterization teams. These are hands-on, wet lab positions ideal for early-career scientists eager to make an impact and contribute to cutting-edge drug design. www.aiproteins.com/careers

Speaking as someone who had a career in academia before industry - there are many things I love about academia, but my job satisfaction is higher in industry. I hope things get better for all my friends in academia, because switching isn't the solution for everyone. www.nature.com/articles/d41...

nature.comIndustry scores higher than academia for job satisfactionNature’s salary survey finds that industry researchers are more positive about their careers. Academia must raise its game.

Chris Bahl reposted

We've got Jeff Gray (graylab.jhu.edu) coming to present this month!! Wednesday, February 25th 2026, starting at 7pm EST in Room 181, Building 68, @MIT "Antibody language models vs. biology; protein docking denoising diffusion models vs. physics" bpdmc.org

bpdmc.orgscheduleintroduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

I appreciate all the congratulations for our Series A! I also want to make sure we don't forget an important truth Funding is not the finish line. We're grateful for the resources we have, and my promise is that we'll continue to do everything in our power to make a difference

AI Proteins@aiproteins.com

AI Proteins has closed a $41.5 million Series A financing to accelerate the development of de novo #miniproteins! The round was led by Mission BioCapital and SANTÉ, with robust participation from existing investors. See the official press release for details: www.businesswire.com/news/home/20...

Now, we’re using these capabilities to develop purpose-built #miniprotein medicines designed to match the complexity of human disease.

To truly control biology, we need medicines that can engage multiple targets simultaneously, but traditional modalities like small molecules and antibodies struggle to do this.

In this talk, I explain how our #miniproteins can interact with as many targets as needed to deliver the exact therapeutic outcome that patients require. This level of sophistication is unprecedented and will impact indications across oncology, inflammation, and beyond.

Biology is dizzyingly complex, and yet almost every medicine humanity has ever made acts on a single target in the body. Just a handful can interact with two distinct targets, and these are some of the most exciting treatments to enter the clinic in the past decade.

Chris Bahl reposted

Join us in Room 181, Building 68 @mit.edu on October 22nd 2025 @ 7pm EDT to see @grocklin.bsky.social present a mind blowing amount of data and learn what becomes possible at this scale "Predicting protein folding stability and aggregation propensity using large-scale experiments" bpdmc.org

bpdmc.orgscheduleintroduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

We're looking for a mass spec expert to join our team at @aiproteins.com! This position is ideal for a freshly-minted PhD grad (or someone who will graduate within the next 6 months or less), or a rockstar scientist who earned their skills on the job in biotech

AI Proteins@aiproteins.com

We're #hiring a Scientist in Mass Spectrometry! Apply today or share this post with your network: www.linkedin.com/jobs/view/42... (ignore what linkedin says - the search is still open) Interested? Please email your CV to: careers@aiproteins.bio

View full thread
View full thread

Our mission is to industrialize drug discovery to create programmable, #denovo protein-based medicines that help patients across a wide range of diseases

What began as an idea — that we could scale de novo protein design — is now a fully-operational platform that integrates generative #AI with automated production and characterization in the wet lab

This was a lot of fun - thanks so much @yossefbaidi.bsky.social and @fang-xie.bsky.social ‪for the great conversation, and for your passion and excitement for biotech and entrepreneurship!

Yossef Baidi@yossefbaidi.bsky.social

During this episode, @fang-xie.bsky.social and I interview @cdbahl.com, co-founder and CEO of @aiproteins.com. We discuss with Chris his interest in protein science and how he started his academic lab at the @ipiproteins.bsky.social.