Arjuna Rajakumar PhD

Arjuna Rajakumar PhD

@arjunarajakumar.bsky.social

EvoDevo biologist - Post Doc Lehmann lab Whitehead Institute ants + flies germ cells, eusociality & endosymbisis

1.8K followers1K following21 posts

First paper published from Rajee's lab! A sign of great things to come!

Rajendhran Rajakumar@rajeerajakumar.bsky.social

Breaking trait scaling via the evolution and regulation of dimorphic decoupling in ants | PNAS www.pnas.org/doi/10.1073/... #Ants #Pheidole 🐜 @uottawa.ca @uottawascience.bsky.social

Arjuna Rajakumar PhD reposted

New co-authored paper from a member of JEZ-B’s rising star board: Arjuna Rajakumar

Arjuna Rajakumar PhD@arjunarajakumar.bsky.social

So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6...

Excited to share some of our new work on Queen and Worker caste determination in ants!! Especially, the surprisingly role early embryonic development plays!

Virtual Gastrulation Zoom Talks@vgzt2021.bsky.social

🐜 Ant societies meet embryonic mechanics! Join @arjunarajakumar.bsky.social and @surajshankar.bsky.social for two fascinating talks exploring caste determination and robust fate timing. 📅 Oct 2 | ⏰ 10 AM ET / 7 AM PT 🔗 Scan the poster’s QR code to join us and bring your questions! #evodevo #dev

Love ant oogenesis!

Ingrid Fetter-Pruneda, Ph.D.@ifetter.bsky.social

Thrilled to share the first full paper from @AntLabUNAM! 🐜💥 Our paper examines how queen and worker harvester ants differ in ovarian morphology and gene expression, shedding light on the ovary as a hub for multiple physiological systems, not just reproduction. Check it out! rdcu.be/ePNP8

Arjuna Rajakumar PhD reposted

Arjuna Rajakumar PhD reposted

One of the best studied places in Drosophila and they find stunning new things. Biology never stops giving 🧪

Arjuna Rajakumar PhD@arjunarajakumar.bsky.social

So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6...

Arjuna Rajakumar PhD reposted

This work would not have been possible without the incredible snATAC-seq atlas of the Drosophila embryo from @diegoisworking.bsky.social @jshendure.bsky.social and @eileen-furlong.bsky.social which helped us discover that germ cells retain a totipotent chromatin state throughout development!

Arjuna Rajakumar PhD@arjunarajakumar.bsky.social

So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6...

Arjuna Rajakumar PhD reposted

Incredibly excited to share my new preprint! 🪰🧬 Ever wondered how germ cells can specify their fate without having a dedicated transcriptional program? We found that germ cells keep the uncommitted chromatin state of the early embryo www.biorxiv.org/content/10.6...

biorxiv.orgDecoupling Transcription from Cell Fate Preserves Germ Cell TotipotencyOnly germ cells can give rise to a totipotent embryo, yet a conserved transcriptional program for germ cell identity remains elusive. Profiling Drosophila primordial germ cells (PGCs) across embryogen...
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Lost children are the first germ cells to die during embryogenesis, they fail to undergo trans-epithelial migration and are lost in the gut. When we rescue their death with chk2 mutants they still retain maternal transcripts and do not express zygotic transcripts. 7/8

Always a pole cell never a pgc! Transcription may be essential to segregate healthy and defective pole cells. Pole cells that never activate their zygotic genome and retain what mommy gave them, die. Pole cells that activate their zygotic genome too much also die. Life is a balance! 8/8

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As It turns out, nanos actually inhibits Zelda protein levels in pole cells! Now we find that pole cells in nanos mutants have a dramatic increase in Zelda protein. Nanos -> Zelda -> class II genes. This sheds new light for how nanos protects germline identity and prevents its somatization. 5/8

Finally, our data uncovered a second unexpected cluster of germ cells that we term lost children. These germ cells are isolated from the 9 to 12 hour AEL window as coalesced germ cells. These germ cells completely retain their maternal transcriptome and never activate zygotic gene expression. 6/8

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We found that while these class II genes are expressed in pole cells, their translation is inhibited by nanos. Unexpectedly, when we examined class II transcription in nanos mutants we found a dramatic increase in their transcription!! 4/8

Arjuna Rajakumar PhD reposted

Polyphenism - one genome producing different forms - is common in eusocial insects. @arjunarajakumar.bsky.social explores the molecular basis for Pharaoh ant caste development. Queens produce two egg types, giving rise to fertile queens or sterile workers, & queen:worker changes over time. #2026SDB

Arjuna Rajakumar PhD reposted

The elongated shape of the #Drosophila #wing is regulated by the Dachsous-Fat signalling pathway, but how? This study shows that mechanical forces regulated by this pathway modulate tissue-wide #cytoskeletal tension to orient growth during larval development @plosbiology.org 🧪 plos.io/4vp9EOh

Arjuna Rajakumar PhD reposted

Excited to host invited speaker Alexandra Joyner at #2026SDB in Las Vegas! 🎰🃏 Her research explores the genetic regulation of development and how signaling pathways shape tissue patterning and organ formation. 🧬✨ #devbio #developmentalbiology #genetics #SDB2026

Arjuna Rajakumar PhD reposted

Excited to announce the Arsenault Lab is launching this fall at Mississippi State! We'll be using ants as a model to tackle fundamental questions in evolutionary biology and evo-devo through genetics and genomics techniques. Please reach out if you're interested, or share with someone who might be!

Arjuna Rajakumar PhD reposted

Arjuna Rajakumar PhD reposted

Arjuna Rajakumar PhD reposted

Please don’t stop sharing and posting your science because of the current attack on it, it is still valuable and reminds us what the fight is for

Arjuna Rajakumar PhD reposted

Incredibly excited to rejuvenate my scientific social network on Bluesky! Current and past research interests include germline immortality, protein folding and organelle remodeling during development. Looking forward to what lies ahead!

Arjuna Rajakumar PhD reposted

Arjuna Rajakumar PhD reposted

Arjuna Rajakumar PhD reposted

Replying to @epimechfc.bsky.social

About Traction Force Microscopy bsky.app/profile/epim...

epithelial mechanics fan club@epimechfc.bsky.social

Cells are strong & generate forces while interacting with their environment. Traction Force Microscopy has been instrumental in measuring these forces, revealing the underlying mechanics. Let's explore pioneering papers in this 🧵by @onenimesa.bsky.social & @juliaeckert.bsky.social

Arjuna Rajakumar PhD reposted

Want to be amazed by how a symbiont can be located at the center of a cell while still being an epibiont! Please read and be amazed by the symbiosis between Anaerameoba and sulfate-reducing bacteria! Now out in Nature Communications (open access)! rdcu.be/dZGNe (1/11)

rdcu.beA unique symbiosome in an anaerobic single-celled eukaryoteNature Communications - Symbiont-housing structures are well-studied in multicellular eukaryotes but rarely in unicellular protists. This study shows that low-oxygen-adapted Anaeramoebae have...