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TIL that Heisenberg did his PhD on fluid dynamics, specifically turbulence. That turned out to be really hard, so later on he switched to something easier, quantum physics

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It was the most computational field at the time and that pushed him to have a very computational approach for his groundbreaking Umdeutung paper. Helped that he had a very computational PhD supervisor(and apparently excellent given the number of Nobel prizes he mentored)

I once read an introductory book on macro economics and the author claimed that Albert Einstein started with economics first and found it too hard, so he switched to theoretical physics. I was not 100% convinced.