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Bind Research
@bindresearch.org

Check out the first tool from Bind Research: SpinForecast. #NMR is one of the most powerful tools for probing the atomic behaviour of IDPs. But the data can look like a Jackson Pollock painting: a sea of peaks that we must painstakingly match to positions along the protein backbone.

Bind Research
@bindresearch.org

This Sudoku-like puzzle is called assignment, and for gnarly IDPs, it can take weeks to solve. Our recent work combines data from the BMRB with predictions from AlphaFold2 to generate probabilistic assignments for IDPs, streamlining this process.

Bind Research
@bindresearch.org

We tested SpinForecast against independently determined assignments for IDPs of increasing size and complexity. Across fully disordered proteins, it assigned approximately 40–75% of signals with 100% confidence, and those assignments were more than 99% accurate. #NMRchat #NMR #ChemSky

Bind Research
@bindresearch.org

For the remaining signals, it returned a ranked shortlist of likely candidates, with the correct residue appearing on that shortlist more than 97% of the time.

Bind Research
@bindresearch.org

Fellow disordered protein 🍝 and NMR nerds 🧲: check out the preprint: www.biorxiv.org/content/10.6...

biorxiv.orgSpinForecast: chain-free probabilistic backbone assignment of intrinsically disordered proteins from NMR chemical shiftsAssigning peaks in NMR spectra to specific residues is an essential but time-consuming step in the study of intrinsically disordered proteins (IDPs). Conventional approaches rely on building chains of...

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