Post

Reffsin, Miller, Cherry & Raj et al. discover that intrinsic cell states determine which cells become infected with SARS-CoV-2. Using single-cell clone tracing, they identified a TIG1-high state marking highly susceptible cells. What makes these cells vulnerable? 👇🏻 1/3

Cells in the TIG1-high state express factors like AXL, TSPAN8, and MUC20 that promote viral entry. Knocking out these genes reduced infection. Importantly, only a subset of ACE2-expressing cells are TIG1-high, explaining why not all permissive cells get infected. How is this relevant? ⤵️ 2/3