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William DeWitt
@wsdewitt.github.io

This started in 2019 as daydreamy PhD student musings with Tatsuya Araki. We're as excited as ever about germinal centers as a platform for experimental evolution. Many thanks to PIs @victora.bsky.social @matsen.bsky.social, co-1st authors Ashni Vora and Tatsuya, and many other key collaborators!

cell.comReplaying germinal center evolution on a quantified affinity landscapeAntibody affinity maturation results from a somatic evolutionary process that takes place in the germinal center. A “parallel replay” experiment on germinal center B cells reveals the evolutionary for...
William DeWitt
@wsdewitt.github.io

...especially @tylernstarr.bsky.social for the deep mutational scan (DMS). This crucial genotype-phenotype map enabled us to understand GC evolutionary dynamics at the level of evolving molecular phenotypes (binding affinity and expression).

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