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Amazing physical chemical analysis of chromosome condensation and decondensation from Andrew Beel, PJ Mattei, and Roger Kornberg. I was tickled to see some expressions that I am used to from Roger's writing in the paper www.science.org/doi/10.1126/...

science.orgThe eukaryote chromosome, a two-state system with interconversion by a volume phase transitionThe formation of metaphase chromosomes requires the activity of condensins, DNA translocases that reduce chromosomal length through the process of loop extrusion. Reduction of length, however, does no...

Nicholas Mancuso

@nmancuso.bsky.social

14 Aug

Not my area, but the writing was -beautiful-. I just wish I understood the implications better (and also wish I was a better writer!).

Craig Kaplan

@triggerloop.bsky.social

This project looks like it was Andrew’s DP5 work - though I feel everyone must have worked together on it. Just want to give credit on the theoretical work to Andrew as the paper indicates. But recognizable touches to me from Roger were in the writing

14/8/26, 6:34 pm0 reposts1 like

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