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The Guinness record is 12 using 4000 ft of toilet roll

The Guinness World Record is 12 folds. The record holder used tissue paper 4000ft long and was the first to achieve 9, 10, 11, and 12 folds. guinnessworldrecords.com/world-record...

Mythbusters cheated (surprise surprise) They taped pieces of paper together to create a giant sheet. Folding that in half only created 2 sheets of paper stacked.

The area halves with each fold. 11 folds is 1/2048. To end at 1ft^2, you're starting with 48,000ft^2, or about 200 feet on a side. To get to 20 folds, it's 1000 feet on a side. Somewhere around 78 folds, your starting sheet is bigger than the observable universe. (I may be off by a couple of folds)

The main issue is that the more folds you have, the thicker the spine you have to create. The inner radius of the spine is negligible, but the outer radius grows exponentially. So it depends on how thin your paper is, and how much you can stretch the paper on those outer layers before it rips.