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Your piece made me think "my brother should read this" and because his birthday is coming up soon, I just ordered the year of physical issues as a gift. I think this is exactly the kind of thing he would want to read, and he always prefers analog to digital, so that's perfect for him!

Thank you!!

There are some great insights here. I spent years in clinical research, and you’re right that misalignment of incentives is one of the biggest bottlenecks in developing and getting patients access to treatments. Well done!

Yeah, I've been saying that my state (Washington) should look into incentives for healthcare focused data centers, while telling the rest to F off.

I had the same exact reaction. Totally inspired. Also immensely frustrated and furious by the setbacks which were absolutely not inevitable.

Well that makes it a must read. Thanks!

Thank you!! That's really kind.

Let's go! Research with impact and meaning. Let's all do more of this and less of "I need a n'th paper this year".

This article is a companion to my TED talk, which comes out next week.

Nicely put! What's frustrating is the $$ required to not only support science but also distribute its bounty are so miniscule compared to existing spending. Ramping up expenditures would dramatically improve quality of life in the long term for token sums relative to GDP. Good science has a big ROI

Great stuff! Just FYI, there are new FDA approved treatments for Alzheimer's disease (though they are risky and not very effective). E.g. www.nejm.org/doi/full/10.... Your argument about incentives is convincing. But why should the task of drug development not simply be absorbed into the state?

This is a great piece, but also your writing is so direct, organized, and clear. Very impressive, thank you for it!