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The story of scale up of streptomycin for treating TB is an epic one, involving George Merck and his pharmaceutical company--just making enough to do the clinical trial was a challenge newsnetwork.mayoclinic.org/discussion/d...
Thank you, so interesting! I was reading earlier about how it was discovered by Waksman and then-PhD student Albert Schatz. It seems Schatz was drafted into WWII while working on the project. He returned to the lab a few months later after an injury, and then discovered streptomycin.
Strange to imagine what it might have been like if he hadn't returned - maybe someone else in Waksman's lab would have discovered it, but a while later? I hadn't read about the problems with scaling it up for trials though, really interesting
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