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Open Targets
@opentargets.org

Ambitious science can start in the most unglamorous places. In 2015, gastroenterologist Tim Raine and geneticist Carl Anderson had a casual conversation in an underground carpark, which led to the largest single-cell dataset of Inflammatory Bowel Disease (IBD)-relevant tissues

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Open Targets
@opentargets.org

After persuading funding bodies—Open Targets, the @sangerinstitute.bsky.social, and the Crohn’s and Colitis Foundation—that this was worth the gamble, they launched the “IBDverse”, and processed almost 1200 samples from over 600 patients. Nothing on this scale had ever been attempted before.

Open Targets
@opentargets.org

This work, the largest study of its kind, was recently published in Nature and Nature Genetics. Find out more about the origins of the IBDverse on the blog: blog.opentargets.org/origins-of-t...

blog.opentargets.orgOrigins of the IBDverse: how a conversation in a carpark became one of the largest gut cell studiesIn 2015, Tim Raine and Carl Anderson had the ambitious idea of using single-cell sequencing to gain insights into the genes and cell types causally driving Inflammatory Bowel Disease (IBD), a project ...