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Open Targets
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“We hope our framework will help drive a conceptual shift in how MASLD is studied and understood.” A new study reframes Metabolic dysfunction-Associated Steatotic Liver Disease as a continuous process, better capturing the underlying disease biology www.nature.com/articles/s42...

nature.comA data-driven framework reconstructs the molecular continuum of human MASLD progression - Nature MetabolismA trajectory-based molecular framework reveals coordinated temporal shifts in metabolic, inflammatory and fibrogenic mechanisms across the human MASLD spectrum.
Open Targets
@opentargets.org

Published in Nature Metabolism, the study establishes a methodology to integrate multi-modal MASLD patient data, by anchoring changes in gene expression to the histological changes that characterise MASLD progression and are common to all patients

Open Targets
@opentargets.org

Using this methodology, the team created a MASLD-related regulatory network that captures both signalling pathway activities and cellular response patterns.

Open Targets
@opentargets.org

In parallel, they used a histology-based patient ranking to stratify patients into sequential overlapping groups, to capture the continuous trajectory of the disease.

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Open Targets
@opentargets.org

This provides a starting point to deciphering the mechanisms that underpin MASLD, which could lead to better treatments and diagnosis of patients. Their approach could be applied to similar diseases where access to longitudinal data is challenging www.nature.com/articles/s42...

nature.comA data-driven framework reconstructs the molecular continuum of human MASLD progression - Nature MetabolismA trajectory-based molecular framework reveals coordinated temporal shifts in metabolic, inflammatory and fibrogenic mechanisms across the human MASLD spectrum.