Nature research paper: Computational design of metalloproteases go.nature.com/3Ut8tRx
go.nature.comComputational design of metalloproteases - NatureRFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.
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