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Coming to #Python #Pandas from NumPy? You'll reach for np.isnan: s = Series([10, np.nan, 30]) s.loc[ ~np.isnan(s) ] # returns 10, 30 Unfortunately, this works. Better, use s.isna (or s.isnull). But the best way to drop NaN? Use dropna: s.dropna() # returns 10, 30