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Insights from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/... #Tuberculosis

28/10/25, 4:01 pm5 reposts8 likes

Journal of Experimental Medicine

@jem.org

28 Oct 2025

Cooper highlights recent JEM studies from @wjbranchett.bsky.social et al. (rupress.org/jem/article/...) and @bengern.bsky.social et al. (rupress.org/jem/article/...)

rupress.orgType I IFN drives neutrophil swarming, impeding lung T cell–macrophage interactions and TB control | Journal of Experimental Medicine | Rockefeller University PressThe early immune mechanisms determining M. tuberculosis infection outcome are unclear. Type I signaling early during M. tuberculosis infection favors neutr