ISB on Mythryl: “A new study co-led by ISB and published in the journal Cell Reports…”

A new study co-led by ISB and published in the journal Cell Reports Medicine reveals how a rare lung cancer can shift between cell types, pass through hybrid states, and build distinct tumor “neighborhoods” that may help it evade detection and resist treatment.

Cell Reports Medicine@cp-cellrepmed.bsky.social

Online now: Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small-cell lung cancer

dlvr.itSpatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small-cell lung cancerWang et al. map combined small-cell lung cancer (cSCLC) with spatial multi-omics, showing that mixed histologies arise from a single clone that diversifies through neuroendocrine plasticity and stromal partitioning. The resulting niche map highlights why microenvironment programs diverge and supports mutation-based detection of cSCLC from small biopsies and blood.

13/4/26, 2:50 pm0 reposts0 likes

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