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The Brain Prize
@brainprize.org

For some people, the causes of stroke was a mystery. Read how the answer to the riddle lay in our genes in the Frontiers for Young Minds Brain Prize collection. https://kids.frontiersin.org/articles/10.3389/frym.2026.1784148 #Neuroscience #BrainPrize

kids.frontiersin.orgCADASIL: From Medical Mystery to Scientific DiscoveryIn this article, you will discover how studying one unusual family led us to identify CADASIL, a genetic disease that damages the brain’s small blood vessels. You will learn how we found that changes in a protein called NOTCH3 cause it to build up around these vessels, forming clumps that lead to the loss of important vessel cells. You will also explore how this discovery helped solve a 25-year mystery about how the disease works. Finally, you will read about the biggest open questions in the field and how this research is guiding new treatments and helping us understand many other brain...

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